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ASSESSMENT OF RENAL FUNCTION IN GERIATRICS

Festus O. O., Obodo B. N, Malachi E. E., Idewele E. I., Akele E. J., Ohiwerei W. O

Abstract


This study was designed to assess renal function in geriatrics.  A total number of 100 subjects were recruited for this study which consists of 70 geriatrics and 30 young adults serving as the control. Venous blood samples were taken from all the subjects including the control to estimate the levels of bicarbonate, chloride, potassium, sodium, creatinine and urea. Sodium and potassium levels were estimated using flame photometric method. Creatinine and urea were estimated using the Jaffe’s method and Urease-Bertholot’s methods respectively. Bicarbonate was estimated using titration method while chloride was estimated using schales and schales method. The mean and standard deviation obtained for bicarbonate in geriatrics are 24.68 ± 3.43 mmol/L while that of the control is 24.73 ± 3.98 mmol/L; and when compared statistically, there was no significant difference (P>0.05) between the values obtained. Also there was no significant difference (P> 0.05) when the levels of serum chloride in geriatrics (97.06 ± 5.55 mmol/L) were compared with that of the control (96.83 ± 6.46 mmol/L).  The mean and standard deviation obtained for potassium in geriatrics are 4.57 ± 4.35 mmol/l while that of the control is 4.15 ± 0.42 mmol/l; and when compared statistically, there was no significant difference (P>0.05) between the values obtained. Also there was significant difference (P< 0.05) when the levels of serum sodium in geriatrics (136.55 ± 16.57 mmol/l) were compared with that of the control (141.07 ± 2.63 mmol/l). Furthermore, the mean and standard deviation obtained for serum creatinine among geriatrics and control are 0.49 ± 0.33 mg/dl and 0.61 ± 0.26 mg/dl respectively. When compared statistically there was a significant difference (P≤ 0.05) between values obtained. Similarly, there was significant difference (P< 0.05) when the levels of serum urea in geriatrics (28.52 ± 15.22 mg/dl) were compared with that of the control (32.61 ± 9.87 mg/dl). The result of this study proved that serum electrolytes, creatinine and urea in geriatrics are altered and hence supporting the facts from other researchers that old age affects renal function.


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Anderson, S., Halter, J.B., Hazzard, W.R., Himmelfarb, J., Horne, F.M. and Kaysen, G.A. (2009): Prediction, progression, and outcomes of chronic kidney disease in older adults. J Am Soc Nephrol 20: 1199-2209.

Anderson, S., Halter, J.B., Hazzard, W.R., Himmelfarb, J., Horne, F.M. and Kaysen, G. (2009): Prediction, progression, and outcomes of chronic kidney disease in older adults. J Am Soc Nephrol 20: 1199-1209.

Clark, B. (2000)Biology of renal aging in humans. Adv Ren Replace Ther 7:11-21.

Coresh, J., Astor, B.C., Greene, T., Eknoyan, G. and Levey, A,S. (2003): Prevalence of chronic kidney disease and decreased kidney function in the adult US population. Third National Health and Nutrition Examination Survey. Am J Kidney Dis 41: 1– 12.

Coresh, J., Selvin, E., Stevens, L.A., Manzi, J., Kusek, J.W., Eggers. P., Van, Lente, F. and Levey, A.S. (2007): Prevalence of chronic kidney disease in the United States. JAMA 298: 2038– 2047.

Davies, I., Fotheringham, A.P. and Faragher, B.E. (1989): Age-associated changes in the kidney of the laboratory mouse. Age Ageing; 18:127-133.

Epstein, M. (1996): Aging and the kidney. J Am Soc Nephrol; 7:1106-1122.

Fabiny, D.L. and Ertingshausen, G. (1971): Automation reation-rate method for determination serum creatinine with centrifichem. Clin. Chem., 17: 696-700.

Harman, D. (2003): Aging and oxidative stress. J Int Fed Clin Chem., 10:24-27.

Hemmelgarn, B.R., Zhang, J., Manns, B.J., Tonelli, M., Larsen, E. and Ghali, W.A. (2006): Progression of kidney dysfunction in the community-dwelling elderly. Kidney Int., 69: 2155-2161.

Hirokawa, K. (1975): Characterization of age-associated kidney disease in Wistar rats. Mech Ageing Dev., 4:301-316.

Hsieh, M. and Power, D. (2009): Abnormal Renal Function and Electrolyte Disturbances in Older People. Journal of Pharmacy Practice and Research 230 39 (3): 230-234.

Levey, A.S., Stevens, L.A., Schmid, C.H., Zhang, Y.L., Castro, A.F., Feldman, H.I. and Kusek, J.W. (2009): CKD-EPI (Chronic Kidney Disease Epidemiology Collaboration). A new equation to estimate glomerular filtration rate. Ann Intern Med 150: 604– 61.

Lindeman, R.D., Tobin, J. and Shock, N.W. (1985): Longitudinal studies on the rate of decline in renal function with age. J Am Geriatr Soc 1985; 33: 278-285.

Luckey, A.E. and Parsa C.J. (2003): Fluid and electrolytes in the aged. Arch Surg.,138: 1055-1060.

Martin, J.E. and Sheaff, M.T. (2007): Renal ageing. J Pathol., 211:198-205.

Ochie, J. and Kolhatkar, A. (2000): Medical Laboratory Theory and Practice. Tata McGraw-Hill Publishing Company Limited, New Delhi. 116-118.

Odonkor, P.O., Addae, S.K. and Yamamoto, S. (1984): Effect of dietary nitrogen on urinary excretion of nonprotein nitrogen in adolescent sickle cell patients. Hum. Nutr.Clin.Nutr., 38:23-29.

Sunderam, S.G. and Mankikar, G.D. (1983): Hyponatraemia in the elderly. Age Ageing 1983; 12: 77-80.

World Gazetteer (2007): Population of Cities, news, divisions. htt://world gazetteer.com/ng.php. Retrieved on 23/05/2008.

Zhou, X.J., Rakheja, D., Yu, X., Saxena, R., Vaziri, N.D. and Silva, F.G. (2008) The aging kidney. 74:710-720.


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