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Unveiling the Power of Beta-Blocking Agents in Human Health

Ramanjaneyulu D. V., Sravani Pragna K., Muralinath E., Kalyan C. Chakravarthi, Sony Sharlet E., Sai Hemachand N., Manjari P., Sravani K., Guru Prasad M., Sai Kumar M., Poojitha P., Bharat M., Bharat M., Gnana Lahari R.

Abstract


Beta_ blocking agents , also termed as beta_ blockers, have revolutionized the landscape of Cardio vascular medicine  since their discovery in the mid 20th century. Originally  developed  to manage heart conditions, beta blockers have since found utility in treating  a wide array of ailments, from hypertension to anxiety disorders. By antagonizing beta_ adrenergic receptors, beta_ blockers inhibit the effects of catecholamines like increased heart rate, blood pressure and contractility.  Beta-blockers are extremely helpful in the treatment of illnesses such as hypertension, angina, and heart failure since this blocking reduces cardiac workload and oxygen consumption. Clinical applications include  cardio vascular disorders, heart failure and anxiety as well as performance anxiety. Glaucoma and migraine  prophylaxis. It is finally concluded that beta_ blocking agents represent a versatile class of medications with diverse therapeutic applications in human health.


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do Vale GT, Ceron CS, Gonzaga NA, Simplicio JA, Padovan JC. Three Generations of β-blockers: History, Class Differences and Clinical Applicability. Curr Hypertens Rev. 2019;15(1):22-31. [PubMed]

Steenen SA, van Wijk AJ, van der Heijden GJ, van Westrhenen R, de Lange J, de Jongh A. Propranolol for the treatment of anxiety disorders: Systematic review and meta-analysis. J Psychopharmacol. 2016 Feb;30(2):128-39. [PMC free article] [PubMed]

Gorre F, Vandekerckhove H. Beta-blockers: focus on mechanism of action. Which beta-blocker, when and why? Acta Cardiol. 2010 Oct;65(5):565-70. [PubMed]

Rehsia NS, Dhalla NS. Mechanisms of the beneficial effects of beta-adrenoceptor antagonists in congestive heart failure. Exp Clin Cardiol. 2010 Winter;15(4):e86-95. [PMC free article] [PubMed]

Machackova J, Sanganalmath SK, Elimban V, Dhalla NS. β-adrenergic blockade attenuates cardiac dysfunction and myofibrillar remodelling in congestive heart failure. J Cell Mol Med. 2011 Mar;15(3):545-54. [PMC free article] [PubMed]

Fares A. Night-time exogenous melatonin administration may be a beneficial treatment for sleeping disorders in beta blocker patients. J Cardiovasc Dis Res. 2011 Jul;2(3):153-5. [PMC free article] [PubMed]

Weir MR. Beta-blockers in the treatment of hypertension: are there clinically relevant differences? Postgrad Med. 2009 May;121(3):90-8. [PubMed]

Marques de Mello L, Cruz ÁA. A proposed scheme to cope with comorbidities in asthma. Pulm Pharmacol Ther. 2018 Oct;52:41-51. [PubMed]

Soma K, Yao A, Saito A, Inaba T, Ishikawa Y, Hirata Y, Komuro I. Regular Treatment Strategy with a Large Amount of Carvedilol for Heart Failure Improves Biventricular Systolic Failure in a Patient with Repaired Tetralogy of Fallot. Int Heart J. 2018 Sep 26;59(5):1169-1173. [PubMed]

Etchegoyen CV, Keller GA, Mrad S, Cheng S, Di Girolamo G. Drug-induced QT Interval Prolongation in the Intensive Care Unit. Curr Clin Pharmacol. 2017;12(4):210-222. [PubMed]

De Vecchis R, Ariano C, Di Biase G, Noutsias M. Acquired drug-induced long QTc: new insights coming from a retrospective study. Eur J Clin Pharmacol. 2018 Dec;74(12):1645-1651. [PubMed]

Farzam K, Tivakaran VS. StatPearls [Internet]. StatPearls Publishing; Treasure Island (FL): Jul 2, 2023. QT Prolonging Drugs. [PubMed]

Graudins A, Lee HM, Druda D. Calcium channel antagonist and beta-blocker overdose: antidotes and adjunct therapies. Br J Clin Pharmacol. 2016 Mar;81(3):453-61. [PMC free article] [PubMed]

Hoedemaker NP, Roolvink V, de Winter RJ, van Royen N, Fuster V, García-Ruiz JM, Er F, Gassanov N, Hanada K, Okumura K, Ibáñez B, van 't Hof AW, Damman P. Early intravenous beta-blockers in patients undergoing primary percutaneous coronary intervention for ST-segment elevation myocardial infarction: A patient-pooled meta-analysis of randomized clinical trials. Eur Heart J Acute Cardiovasc Care. 2020 Aug;9(5):469-477. [PMC free article] [PubMed]

Suissa S, Ernst P. Beta-Blockers in COPD: A Methodological Review of the Observational Studies. COPD. 2018 Oct;15(5):520-525. [PubMed]


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