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A Requisite Parameters of Noro Virus Include Etiology, Epidemiology, Patho Physiology, Diagnosis, Differential Diagnosis, Treatment, Prognosis, Complications and Consultations

Muralinath E., Srinivas G., Ramanjaneyulu D. V., Dr. D Satyanarayana Murthy, Guruprasad M., Sravani Pragna K., Manjari P., Sony Sharlet E., T. Nikhil, V. Yaswanth Sai, D. Kusuma Latha, Ch. Ramya Sudha, K. Sridevi, D. Gokul Shiva Balaji

Abstract


The single-stranded RNA, non-enveloped, positive-sense noroviruses belong to the Calici viridae family and are the primary cause of acute gastrointestinal sickness globally. In nations that have rota virus immunization programs, norovirus has since emerged as the most frequent cause of gastroenteritis, particularly in children. Diarrhea, vomiting, nausea, and abdominal discomfort are common symptoms of infection that can lead to dehydration and necessitate medical attention.

 

Management comprises supportive therapies as well as infection control measures like hand hygiene and surface cleaning, which are critical regarding prevention of outbreaks. This course examines the etiology, pathophysiology, diagnostic assessment, therapy, prevention measures, and developing vaccines of the norovirus. This activity explains regarding healthcare professionals and is designed to increase the learner's competence in recognizing noro virus, executing the recommended evaluation, and implementing an appropriate inter professional approach if managing along this condition. 


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References


Sell, J., & Dolan, B. (2018). Common gastrointestinal infections. Primary Care, 45(3), 519–532. https://pubmed.ncbi.nlm.nih.gov/

Sadkowska-Todys, M., Zieliński, A., & Czarkowski, M. P. (2018). Infectious diseases in Poland in 2016. Przegląd Epidemiologiczny, 72(2), 129–141. https://pubmed.ncbi.nlm.nih.gov/

Bonanno Ferraro, G., Brandtner, D., Mancini, P., Veneri, C., Iaconelli, M., Suffredini, E., & La Rosa, G. (2025). Eight years of norovirus surveillance in urban wastewater: Insights from next-generation. Viruses, 17(1). https://pubmed.ncbi.nlm.nih.gov/

Chan, M. C., Lee, N., Hung, T. N., Kwok, K., Cheung, K., Tin, E. K., Lai, R. W., Nelson, E. A., Leung, T. F., & Chan, P. K. (2015). Rapid emergence and predominance of a broadly recognizing and fast-evolving norovirus GII.17 variant in late 2014. Nature Communications, 6, 10061. https://doi.org/10.1038/ncomms10061

Chhabra, P., Wong, S., Niendorf, S., Lederer, I., Vennema, H., Faber, M., Nisavanh, A., Jacobsen, S., Williams, R., Colgan, A., Yandle, Z., Garvey, P., Al-Hello, H., Ambert-Balay, K., Barclay, L., de Graaf, M., Celma, C., Breuer, J., Vinjé, J., & Douglas, A. (2024). Increased circulation of GII.17 noroviruses, six European countries and the United States, 2023 to 2024. Eurosurveillance, 29(39). https://pubmed.ncbi.nlm.nih.gov/

Lappe, B. L., Wikswo, M. E., Kambhampati, A. K., Mirza, S. A., Tate, J. E., Kraay, A. N. M., & Lopman, B. A. (2023). Predicting norovirus and rotavirus resurgence in the United States following the COVID-19 pandemic: A mathematical modelling study. BMC Infectious Diseases, 23(1), 254. https://doi.org/10.1186/s12879-023-08241-w

Atmar, R. L., Ramani, S., & Estes, M. K. (2018). Human noroviruses: Recent advances in a 50-year history. Current Opinion in Infectious Diseases, 31(5), 422–432. https://pubmed.ncbi.nlm.nih.gov/

Crisp, C. A., Jenkins, K. A., Dunn, I., Kupper, A., Johnson, J., White, S., Moritz, E. D., & Rodriguez, L. O. (2023). Notes from the field: Cruise ship norovirus outbreak associated with person-to-person transmission—United States jurisdiction, January 2023. Morbidity and Mortality Weekly Report, 72(30), 833–834. https://doi.org/10.15585/mmwr.mm7230a4

Chio, C. C., Chien, J. C., Chan, H. W., & Huang, H. I. (2024). Overview of the trending enteric viruses and their pathogenesis in intestinal epithelial cell infection. Biomedicines, 12(12). https://pubmed.ncbi.nlm.nih.gov/

Randazzo, W., D’Souza, D. H., & Sanchez, G. (2018). Norovirus: The burden of the unknown. Advances in Food and Nutrition Research, 86, 13–53. https://pubmed.ncbi.nlm.nih.gov/

Bányai, K., Estes, M. K., Martella, V., & Parashar, U. D. (2018). Viral gastroenteritis. The Lancet, 392(10142), 175–186. https://doi.org/10.1016/S0140-6736(18)31128-0

McIntosh, E. D. G. (2018). Healthcare-associated infections: Potential for prevention through vaccination. Therapeutic Advances in Vaccines and Immunotherapy, 6(1), 19–27. https://doi.org/10.1177/2515135518757382

Parrino, T. A., Schreiber, D. S., Trier, J. S., Kapikian, A. Z., & Blacklow, N. R. (1977). Clinical immunity in acute gastroenteritis caused by Norwalk agent. The New England Journal of Medicine, 297(2), 86–89. https://pubmed.ncbi.nlm.nih.gov/

Ford-Siltz, L. A., Tohma, K., & Parra, G. I. (2021). Understanding the relationship between norovirus diversity and immunity. Gut Microbes, 13(1), 1–13. https://doi.org/10.1080/19490976.2020.1909264

De Grazia, S., Bonura, F., Cappa, V., Li Muli, S., Pepe, A., Urone, N., & Giammanco, G. M. (2018). Performance evaluation of a newly developed molecular assay for the accurate diagnosis of gastroenteritis associated with norovirus of genogroup II. Archives of Virology, 163(12), 3377–3381. https://pubmed.ncbi.nlm.nih.gov/

Melgaço, F. G., Corrêa, A. A., Ganime, A. C., Brandão, M. L. L., Medeiros, V. M., Rosas, C. O., Lopes, S. M. D. R., & Miagostovich, M. P. (2018). Evaluation of skimmed milk flocculation method for virus recovery from tomatoes. Brazilian Journal of Microbiology, 49(Suppl 1), 34–39. https://doi.org/10.1016/j.bjm.2018.01.002

Hyun, J., Ko, D. H., Lee, S. K., Kim, H. S., Kim, J. S., Song, W., & Kim, H. S. (2018). Evaluation of a new multiplex real-time PCR assay for detecting gastroenteritis-causing viruses in stool samples. Annals of Laboratory Medicine, 38(3), 220–225. https://doi.org/10.3343/alm.2018.38.3.220

Winder, N., Gohar, S., & Muthana, M. (2022). Norovirus: An overview of virology and preventative measures. Viruses, 14(12). https://doi.org/10.3390/v14122671

Cohen, R., Raymond, J., & Gendrel, D. (2017). Antimicrobial treatment of diarrhea/acute gastroenteritis in children. Archives de Pédiatrie, 24(12S), S26–S29. https://doi.org/10.1016/S0929-693X(17)30783-7

Chen, Y., Hall, A. J., & Kirk, M. D. (2017). Norovirus disease in older adults living in long-term care facilities: Strategies for management. Current Geriatrics Reports, 6(1), 26–33. https://doi.org/10.1007/s13670-017-0202-4


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