Open Access
Subscription Access
A Comprehensive Review on Oral Medicated Jellies
Abstract
The commercial production of oral medicated jellies, which date back to the 20th century, has continued due to consumer demand. The palatable solid dosage form known as oral medicated jellies is provided in the oral cavity and is intended to be dissolved in the mouth or pharynx for its local or systemic effects. Oral medicated jellies provide a number of benefits as a pharmaceutical formulation, but they also have certain drawbacks. Oral medicated jellies can be used as a dosage form for medication delivery via the buccal, gingival, and sublingual routes. Oral medicinal jellies are sold over-the-counter and come in flavors like mango, pineapple, strawberry, and chocolate, etc. They contain a medicine that treats arthritis, erectile dysfunction, and sore throat
Oral medicated jellies are a unique dosage form that offers several advantages, such as ease of administration and improved patient compliance, especially for individuals who have difficulty swallowing solid medications. These jellies are designed to dissolve or disintegrate in the mouth, allowing the active ingredients to be absorbed through the oral mucosa.In terms of efficacy, oral medicated jellies are commonly used for various purposes, including pain relief, antihistaminic effects, and nutritional supplementation. The effectiveness of these jellies depends on factors like the active ingredients, formulation, and patient-specific factors.
They are created utilizing a congealed and heating process. With numerous uses In pharmaceuticals, nutraceuticals, and over-the-counter medications, it serves as a unique dosage form. This review provides formulation scientists with novel applications for this drug delivery technique by focusing on several aspects of the formulation of oral medicated jellies.
References
Hua S. Advances in oral drug delivery for regional targeting in the gastrointestinal tract-Influence of physiological, pathophysiological and pharmaceutical factors. Front Pharmacol. 2020;11:524.
Evaluation 0f Oral Medicated Jelly of Ondansetron Hydrochloride, World Journal of Pharmacy and Pharmaceutical Sciences, 2017; 6(9): 1537-1549.
Beeram V. Formulation, development and evaluation of cefixime oral medicated jelly.Indian Journal of Pharmaceutical science, 2010; 78(2): 68-73.
Gohel MC, Bansal G, Bhatt N. Formulation and Evaluation of Orodispersible Taste Masked Tablets of Famotidine. Pharma Bio World 2005; 3: 75-80.
Chhajed M, Chhajed A, Godhwani T, Tiwari D, “Formulation Development and Evaluation of Unit Moulded Semisolid Jelly for Oral Administration as a Calcium Supplement”. World Journal of Pharmaceutical Research, 2012; I(3): 626-634.
Prakash K, Satyanarayana VM. Formulation Development and Evaluation of Novel Oral Jellies of Carbamazepine Using Pectin, Guar Gum and Gellan Gum. Asian J Pharm, 2014; 8: 2419.
Shargel L, Yuab. Applied Biopharmaceutics and Pharmacokinetics. 4th Ed. Stamford: Appleton and Lange, 2010.
Swamivel Manickam M, Manavalan R, Valliappan K. Mouth Dissolving Tablets: An Overview. International Journal of Pharmaceutical Sciences and Research 2010; 1(12): 43–55.
Tripathi KD. Essential of Medical Pharmacology. Jaypee Brothers Medical, New Delhi, India, 6th ed., 2008; 216–217
Dubey M, Sheth Z, Design and Development of Oral Medicated Jelly of Palonosetron HCl. Paripex-Indian Journal of Research, 2015; 4(6): 253-255.
Jadhav SB, Bharkad VB, Shinde MK, Kadam VS and Katkam P. Development
Gerbino PP. Remington: The Science and Practice of Pharmacy. 21st Ed., Vol. 1. New
Delhi: Lippincott Williams and Wilkins, B.I. Publications Pvt. Ltd.; 2006.
Imai K. Alendronate Sodium Hydrate (Oral Jelly) for the Treatment of Osteoporosis: Review of a Novel, Easy to Swallow Formulation. Clininterv Aging, 2013; 8: 681-8
Eisai Launches New Oral Jelly Formulation Of Aricept, World’s First Oral Jelly Formulation For Alzheimer’s disease Treatment, 2009.Available From: Http://Www.Eisai.Com/News/News200950.Html.[Last Cited On 2014 Jan 21].
Kaneuchi M, Kohri N, Senbongi K, Sakai H, Iseki K. Preparing Oral Dosage Form of Ketamine In The Hospital For Simplicity And Patient Compliance – Preparations Using Agar. Yakugaku Zasshi, 2005; 125: 187-96.
Yoshida M, Hazekawa M, Haraguchi T, Uchida T. Influence of Swallowing Aids on The Adsorption and Palatability of Kremezin. Chem Pharm Bull (Tokyo), 2011; 59: 434-7.
Carter SJ. Cooper and Gunn’s Dispensing for Pharmaceutical Students. 12thed. New Delhi: CBS Publishers and Distributors, 2008; 214-8.
Howard C. Ansell, Nicholas G. Popvich, Loyd V. Allen, “Pharmaceutical Dosage Forms And Drug Delivery System” ( 1995) First Edition; PP 78
Mehta RM.” Vallabh Prakashan, Pharmaceutics – II Second Edition; 2003,: 168-172.
Cooper and Gun, Dispensing for Pharmaceutics, CBS Publishers & Distributors, Daraya Ganj New Delhi, Twelfth Edition.2000,: 214-216.
Kumaresan C,” Orally Disintegrating Tablet -Rapid Disintegration, Sweet Taste, And target Release Profile, pharmainfo..netsep9 2008.
Pfister WR, Ghosh TK. “ Intraoral delivery systems: An overview, current status and Future trends.] in Drug delivery to the oral cavity: Molecules to Market. CRCPress, NY, USA, 2005, 1-40
Smart JD, Lectin-mediated drug delivery in the oral cavity. Adv. Drug Delivery Review. 2004, 56: 481–489.
Sankar V, Hearnden V, Hull K., Juras DV, Greenberg M., Kerr AR, Lockhart PB.,Sastry SV. Atenolol gastrointestinal therapeutic system I. Screening of formulation variables. Drug. Dev. Ind. Pharm. 1997, 23: 157–165
Cooper and Gun. Dispensing For Pharmaceutics, CBS Publishers & Distributors, Daraya Ganj New Delhi, 12 th Edition, 2000; 214-216.
Robinson JR , Marcel Dekker; Lee VH. Conventional drug delivery system .2(3)1987, 4-15.
Narasimharao N,P.Srinivasababu,S.SumanthaE.Amala,P.N.Abhishekvarma, Ayesha B.Rohini,N. Bharath, Indian Journal of Research in Pharmacy and Biotechnology volume 5 , Issue 3, 2017Journal homepage: http://www.ijrpb.com 5(3): 220 Kanika Nayaka, Manoj kumar mishra, Garima varmaindo-American journals of pharmaceutical sciences.iasjps 2016,3(10) 1276-1282.
Shirse P. Formulation and Evaluation of Oral Medicated Gelly Containing Cyclodextrin Inclusion Complexed Water Insoluble Drug – Glimipiride; IJPRD, 2011; 4(4): 142-153.
Raja Manali M.: Oral Medicated Jelly: A Recent Advancement in Formulation. An International Journal Of Pharmaceutical Sciences, 2016; 7(2): 13-20.
Prakash K, Satyanarayana VM, Nagiat HT, Fathi AH, Shanta AK, Prameela AR. Formulation development and evaluation of novel oral jellies of carbamazepine using pectin, guar gum, and gellan gum. Asian J Pharm. 2014;8:241–17
Patil AN, Chaudhary S, Shah H. Formulation and Evaluation of Levocetrizie Dihydrochloride Soft Gel for Oral Administration; IJPRBS, 2016; 5(2): 178-198.
Refbacks
- There are currently no refbacks.