A Review on Heterocyclic Compound Containing Anticancer Agent, As A Medicinal Chemistry Perspective

Abstract

One of the main causes of death in the globe is cancer. Cancer is caused by gene and protein regulation errors in cells. Despite their side effects, surgery, radiation therapy, and the use of anticancer drugs constitute the contemporary cancer therapy. Heterocyclic chemistry is the general field of study. The article's goal is to cover the most current developments in heterocyclic nitrogen compounds as potential cancer chemotherapeutic agents. Heterocyclics make up more than 80% of new medications, and those that contain nitrogen have better pharmacological effects than those that do not. Compounds containing nitrogen, the foundation of drug development, are an important and valuable class of chemicals that are essential to living cells' metabolism. Medications that are physiologically active comprise more than 85% heterocycles, or at least one heteroatom. We have listed the pharmacological characteristics of FDA-approved heterocyclic medications containing nitrogen atoms in this study. Additionally, we have reported nitrogen-containing heterocycles that are used to treat various cancer types while concurrently covering the cellular targets and biochemical mechanisms of action, such as pyrimidine, quinolone, carbazole, pyridine, imidazole, benzimidazole, triazole, ß-lactam, indole, pyrazole, quinazoline, quinoxaline, isatin, pyrrolo-benzodiazepines, and pyrido[2,3-d]pyrimidines.