Open Access Open Access  Restricted Access Subscription Access

The Impact of Drugs on Lactating Mothers: Considerations and Cautions

Muralinath E., Singh H. S., Vijay Digamber D, Shraddha D, Lalit Kumar S, Kalyan C., Archana Jain, Guruprasad M.

Abstract


Lactating mother's frequently face challenge, if it comes to manage their health especially during breast feeding. The utility of medications needs careful consideration, as a very few drugs can potentially influence both the mother and the infants through breast milk. The chemical properties of a drug play a critical role in it's transfer into breast milk. Lipophilic ( fat_ soluble) drug are more likely to pass into breast milk compare to hydrophilic ( water_ soluble ) Drugs. Drugs with shorter half- lives are normally cleared from the blood in a rapid manner, decreasing the duration of the potential exposure through breast milk. The mother metabolic rate affects how quickly drugs are processed in her body, influencing the concentration of drugs in breast milk. Acetaminophen is normally considered safe particularly during breast feeding, while NSAIDs such as ibuprofen are preferred over stronger pain medications namely opioid.

Selective serotonin re uptake inhibitors ( SSRIs ) are normally prescribed for postpartum depression and are normally considered safe. Certain anti hypertensive medications can be helpful particularly during lactation. But healthcare provider may require to adjust the dosage or choose alternatives to decrease exposure to the infant. Consuming medications immediately after breastfeeding can assist in minimizing the concentration of drugs in breast milk. This allies for a longer internal before the next nursing session. Finally it is concluded that balancing the need for medications with the well_ being of a breast feeding infant needs careful consideration.


Full Text:

PDF

References


Ventrella D, Forni M, Bacci ML, Annaert P. Non-clinical Models to Determine Drug Passage into Human Breast Milk. Curr Pharm Des. 2019;25(5):534-548. [PubMed]

Levine S, Muneyyirci-Delale O. Stress-Induced Hyperprolactinemia: Pathophysiology and Clinical Approach. Obstet Gynecol Int. 2018;2018:9253083. [PMC free article] [PubMed]

Hård AL, Nilsson AK, Lund AM, Hansen-Pupp I, Smith LEH, Hellström A. Review shows that donor milk does not promote the growth and development of preterm infants as well as maternal milk. Acta Paediatr. 2019 Jun;108(6):998-1007. [PMC free article] [PubMed]

Bernard V, Young J, Binart N. Prolactin - a pleiotropic factor in health and disease. Nat Rev Endocrinol. 2019 Jun;15(6):356-365. [PubMed]

Weaver G, Bertino E, Gebauer C, Grovslien A, Mileusnic-Milenovic R, Arslanoglu S, Barnett D, Boquien CY, Buffin R, Gaya A, Moro GE, Wesolowska A, Picaud JC. Recommendations for the Establishment and Operation of Human Milk Banks in Europe: A Consensus Statement From the European Milk Bank Association (EMBA). Front Pediatr. 2019;7:53. [PMC free article] [PubMed]

Hahn-Holbrook J, Saxbe D, Bixby C, Steele C, Glynn L. Human milk as "chrononutrition": implications for child health and development. Pediatr Res. 2019 Jun;85(7):936-942. [PubMed]

Wallace TC, Blusztajn JK, Caudill MA, Klatt KC, Natker E, Zeisel SH, Zelman KM. Choline: The Underconsumed and Underappreciated Essential Nutrient. Nutr Today. 2018 Nov-Dec;53(6):240-253. [PMC free article] [PubMed]

Sampieri CL, Montero H. Breastfeeding in the time of Zika: a systematic literature review. PeerJ. 2019;7:e6452. [PMC free article] [PubMed]

Wei W, Jin Q, Wang X. Human milk fat substitutes: Past achievements and current trends. Prog Lipid Res. 2019 Apr;74:69-86. [PubMed]

Cherkani-Hassani A, Ghanname I, Mouane N. Total, organic, and inorganic mercury in human breast milk: levels and maternal factors of exposure, systematic literature review, 1976-2017. Crit Rev Toxicol. 2019 Feb;49(2):110-121. [PubMed]


Refbacks

  • There are currently no refbacks.