Open Access Open Access  Restricted Access Subscription Access

Community-Based Assessment of Over-the-Counter (OTC) Drug and Food Interaction Awareness in the Rural Population of Greater Noida, Uttar Pradesh

Debjit Das, Dil Prasad Subba

Abstract


This research article is a community-based qualitative cross-sectional study carried out from May 2025  to June 2025 among the residents of Jhundepur village, Greater Noida, Uttar Pradesh, to examine public knowledge of food-drug interactions concerning OTC drugs. One hundred participants from all age groups were surveyed through a 21-item structured questionnaire designed by the Sharda School of Pharmacy. Data management and visualisation were done using Microsoft Excel 2021, Lexicomp, and Google tools. Some intriguing findings were: a very high manipulation rate of OTC drugs with different degrees of awareness of food or dietary interaction among rural populations. Pearson's Chi-square test was applied to draw statistics. Out of 95 respondents who identified themselves by gender, 68.4% were males, whereas 30.5% were females. Hence, the need for targeted educational interventions, such as public information campaigns and better labelling of medicines, to enhance drug safety in the rural setting has been highlighted.


Full Text:

PDF

References


Ana-Maria, P., Rosca, R. O., Georgescu, C., Maftei, N., Mititelu-Tartau, L., Rosca, S., & Tatu, A.-L. (2022). Food-Drug Interactions - A Short Review of the Particularities of Pharmacokinetics and Pharmacodynamics Molecular Stage Correlations. Journal of Pharmaceutical Negative Results, 98–102. https://doi.org/10.47750/pnr.2022.13.s09.011.

Food-Drug Interactions (pp. 21–37). (2023). IGI Global eBooks. https://doi.org/10.4018/978-1-6684-7828-8.ch002.

Wang, Z. P., Xu, W., Liu, D., Li, X., Liu, S., Wu, X., & Wang, H. (2025). Impact of Food Physical Properties on Oral Drug Absorption: A Comprehensive Review. Drug Design Development and Therapy, 19, 267–280. https://doi.org/10.2147/dddt.s497515.

Yadav, Y. C., Pathak, K., & Pathak, D. (2020). Review on Preclinical and Clinical Evidence of Food (Beverages, Fruits and Vegetables) and Drug Interactions: Mechanism and Safety. Current Drug Therapy, 15(1), 12–27. https://doi.org/10.2174/1574885514666190126141424.

Nathasha, J., Nimron, K., K, D., Shaju, M., Jithin, D. S. U., & Baby, D. (2022). An Overview on Drug-Food Interactions. International Journal of Pharmaceutical Sciences Review and Research, 77(2). https://doi.org/10.47583/ijpsrr.2022.v77i02.023.

Dasgupta, A., Reyes, M. A., Risin, S. A., & Actor, J. K. (2008). Interaction of White and Pink Grapefruit Juice with Acetaminophen (Paracetamol) In Vivo in Mice. Journal of Medicinal Food, 11(4), 795–798. https://doi.org/10.1089/JMF.2008.0059.

Al Za’abi, M., Ali, B. H., & Al-Hdhrami, A. (2019). The effect of a single or multiple doses of grapefruit juice on some pharmacokinetic and pharmacodynamic effects of paracetamol in mice. Acta Poloniae Pharmaceutica, 76(4), 753–759. https://doi.org/10.32383/APPDR/105581.

Qinna, N. A., Mallah, E., Arafat, T., & Idkaidek, N. (2012). Effect of licorice and grapefruit juice on paracetamol pharmacokinetics in human saliva.

Baleni, R., Bekker, Z., Walubo, A., & du Plessis, J. (2015). Co-administration of fresh grape fruit juice (GFJ) and bergamottin prevented paracetamol induced hepatotoxicity after paracetamol overdose in rats. Toxicology Reports, 2, 677–684. https://doi.org/10.1016/J.TOXREP.2015.05.004.

Grape Juice on Paracetamol-Induced Hepatotoxicity and Nephrotoxicity. (2024). Journal of Angiotherapy, 8(6). https://doi.org/10.25163/angiotherapy.869743.


Refbacks

  • There are currently no refbacks.