Open Access Open Access  Restricted Access Subscription Access

Modified Simultaneous equation Spectrophotometric Method for Estimation of Azilsartan Medoxomil and Cilnidipine in Combined Dosage Form

Gopal B. Valiya, Jinal H. Shah, Riddhi B. patel, Ashish Ambaliya, Dhavalsinh P. Solanki, Dimal A. Shah

Abstract


Modified Simultaneous equation spectrophotometric method is developed and validated for the simultaneous estimation of Azilsartan Medoxomil and Cilnidipine in Tablet dosage form. zilsartan Medoxomil and Cilnidipine were found to have assimilation maxima (λmax) at 248 nm and 353 nm, separately in methanol. Azilsartan Medoxomil had linear dynamic ranges of 4–24 g/ml, whereas Cilnidipine had linear dynamic ranges of 8–18 g/ml. The developed method was validated as per ICH guideline Q2R1 in terms of Parameters like linearity, precision (intra-day, inter-day and repeatability), accuracy, LOD and LOQ, robustness. The method was applied in the quality control of commercial tablets and proved to be suitable for rapid and reliable quality control.


Full Text:

PDF

References


A.H. Beckette., J.B. Stenlake; Fourth edition part two; Published by S.K. Jain for CBS Publishers & Distributors, 4596/1A, 11 Darya Ganj , New Delhi , pp 275-300, 1988.

Haiying Liu; Department of Chemistry; Michigan Technological University; Houghton, MI 49931 https://www.google.co.in/url?sa=i&rct=j&q=&esrc=s&source=web&cd=&ved=0CAIQw7AJahcKEwjorMXzuu3-AhUAAAAAHQAAAAAQAg&url=https%3A%2F%2Fpages.mtu.edu%2F~hyliu%2Fch4212%2FPowerpoint%2FAn_introduction_%2520to_ultraviolet_Visible.pdf&psig=AOvVaw3RjI6Vfl_NEea98dmOe-ei&ust=1683901183942122

Note for guidance on validation of analytical procedures; Text and methodology (CPMP/ICH/381/95); European Medicines Agency; June 1995.

Sharma S. “Hypertension Therapeutics Update: A Brief Clinical Summary on Azilsartan and Cilnidipine” Hypertension Journal, 1(2), 111-117, 2015.

PubChem. Azilsartan-Medoxomil. Accessed Jan 2023.

https:// pubchem.ncbi.nlm.nih.gov/compound/Azilsartan-medoxomil

PubChem. Cilnidipine. Accessed Jan 2023.

https://pubchem. ncbi.nlm.nih.gov/compound/Cilnidipine

Surwade, K., Saudagar, R. UV spectrophotometric method for the estimation of Azilsartan Medoxomil in bulk and pharmaceutical formulations. World Journal of Pharmacy Research, 2014, 4(1), 1667-1672p.

Gawai M.N., Surwade K.S., Phadatare D.G, “UV Spectrophotometric Method for the estimation of Azilsartan Medoxomil in Bulk Form” indian journals 2018, 11(5), 791-793p.

Aher, S., Saudagar, R. B., “UV-Spectrophotometric Method Development and Validation of Azilsartan Medoxomil in Pharmaceutical Dosage Form” World Journal of Pharmaceutical Research, 2014, 3(6), 840-845p.

Gandhi, S.V., Mittal, P.S., Pahade, A.R., & Rege, S.W. (2015). Development and validation of stability indicating HPTLC method for estimation of azilsartan medoxomil. Pharma Science Monitor, 2015, 6(1), 224-332p.


Refbacks

  • There are currently no refbacks.