The Influence of Drugs on Disorders of Golgi Tendon Organs in Humans

Abstract

Whatever it may be, an influence of drugs on the function of Golgi Tendon Organs (GTO) exhibit profound effects on motor control and may contribute to different types of disorders. If a muscle contracts, the tension on the tendon enhances on the tendon enhances, activating the GTOs. This activation sends signals to the central nervous system, which controls the intensity of muscle contractions to inhibit excessive force that could potentially damage the muscle or tendon .Drugs classified as muscle relaxants, such as benzodiazepines and baclofen, act on the central nervous system to reduce muscle tone and alleviate muscle spasms. Opioid pain killers including morphine and oxycodone, are known to dampen the perception of pain by binding to opioid receptors especially in the brain and Spinal cord. Chronic use of psycho active drugs such as alcohol. Marijuana and certain hallucinogenic can alter perception, cognition and motor coordination. Some athletes may use the performance enhancing drugs, such as anabolic steroids, to enhance muscle mass and strength. While these substances can enhance physical performance in short term, they also increase the risk of muscle and tendon injuries bt overriding the natural feedback mechanisms mediated by GTOS. Altered sensory processing resulting from drug influence on GTOs can contribute to the development of chronic pain syndromes, namely fibromyalgia or complex regional pain syndrome. Finally it is concluded that the influence of drugs on the function of Golgi Tendon Organs can have significant implications for motor control, proprioception and overall musculoskeletal skeletal health.