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Second-Order Derivative Spectrophotometric Method for Simultaneous Estimation of Azilsartan Medoxomil and Cilnidipine in Combined Dosage Form

Dhavalsinh P. Solanki, Ghanshyam B. Paladiya, Dimal A. Shah, Usmangani K. Chhalotiya, Ojas P. Doshi

Abstract


A second-order derivative spectrophotometric method is developed and validated for the simultaneous estimation of Azilsartan Medoxomil and Cilnidipine in Tablet dosage form. The determination of Azilsartan Medoxomil in the presence of Cilnidipine was achieved by measuring the second-order derivative signals at 231 nm, while the second-order derivative signal at 223 nm was measured for the determination of Cilnidipine. The linear dynamic ranges were 4–20 μg /ml for Azilsartan Medoxomil and 1–5 μg/ml for Cilnidipine, the calibration graphs' correlation coefficient was 0.9998, their n-value was 5, their precision (%RSD) was 1.43%, and their accuracy (0.9%) was satisfactory. The detection limits were found to be 2.46 and 1.57 μg/ml for Azilsartan Medoxomil and Cilnidipine, respectively. The method was applied in the quality control of commercial tablets and proved to be suitable for rapid and reliable quality control.


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References


https:// pubchem.ncbi.nlm.nih.gov/compound/Azilsartan-medoxomil

https://pubchem. ncbi.nlm.nih.gov/compound/Cilnidipine

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