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A Review of Coumarin as Antibacterial Agent

Kavitha .S, Baijika .B, Cyril Mathew, Jithamol K. P., Aswani Purandharan

Abstract


Coumarin is the heterocyclic compound formed from benzene and pyrone ring containing oxygen atom. Coumarin derivatives have different biological activities such as anticancer, antimicrobial, antimalarial, antioxidant, antiviral, anti-inflammatory analgesic, antianxiety etc. The synthesised coumarin derivatives were screened for their anti-bacterial activity by means of Disc-well diffusion assay against Gram-positive bacteria and Gram-negative strains. The compounds proved that it is moderate to significant anti-bacterial activity. This review is based on the synthesis of various coumarin derivatives of and its pharmacological actions such as Anti-bacterial activity.


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Aziz Behrami, Kozata Vaso, Sevdie Govori, Islam Krasniqi and Skender Demaku3 Idreiz Vehapi, Synthesis,Characterisation and Antibacterial Activity of some [8-Amino-4,7-dihydroxy-chromen-2-one] , [N-(3-Cyano-4-ethoxy-2-oxo-2H-chromen-7-yl)-formamide] Derivatives. The Comparison with Standard Drug. Research Journal of Pharmaceutical, Biological and Chemical Sciences. ISSN: 0975-8585. Volume III. 2012.

Biljana R. Dekic, Niko S. Radulovic, Vidoslav S. Dekic, Rastko D. Vukice and

Radosav M. Palic, Synthesis and Antimicrobial Activity of New 4-Heteroarylamino Coumarin Derivatives Containing Nitrogen and Sulfur as Heteroatoms, Molecules, ISSN 1420-3049. 2010.

Priscila Lopez-Rojas , Monika Janeczko , Konrad Kubi´ nski ID , Ángel Amesty, Maciej Masłyk, and Ana Estévez-Braun, Synthesis and Antimicrobial Activity of 4-Substituted 1,2,3-Triazole-Coumarin Derivatives, Molecules, MDPI, 2018.

P. Sudhir Kumar, G. Ghosh, S. K. Rout and D. Paul, synthesis and antimicrobial evaluation of some novel 4-hydroxy coumarin derivatives bearing azo moiety, Rasayan journal of chemistry. ISSN: 0974-1496, Volume :6, 2013.

Mohammad Asif, Overview of Diverse Pharmacological Activities of Substituted Coumarins: Compounds with Therapeutic Potentials. American Journal of Current Organic Chemistry. Volume 1, 2014.

Hanhan Dianhar, Qonitatur Rifdah Tristiyane, Alfa Wezy Anugrah Purba and sree Handayani, Antibacterial activities of 3-substituted coumarin-scaffolds synthesised under microwave irradiation, Journal of Hunan university (natural sciences). Volume 49. 2022.

Ichraf Slimani, Naceur Hamdi, Sadeq M. Al-Hazmy, Ibrahim A. Alhagri, El-Zeiny M. Ebeid and Ehab A. Okba. Synthesis and Spectral Characterisation of (E)-3-(3-(4 (Dimethylamino)Phenyl) Acrylo-yl)-4-Hydroxy-2H-Chromen-2-One and Their Antibacterial Activity and Acetylcholinesterase Inhibition, Hindawi Journal of Chemistry, Volume 2021.

M. Sumakanth, m. Sukanya and k. Sruthi, synthesis and antibacterial activity of mannich bases of coumarins, european journal of biomedical and pharmaceutical sciences, ISSN 2349-8870,Volume: 6, 2019.

Hanan M. Alshibl, Ebtehal S. Al-Abdullah, Mogedda E. Haiba, Hamad M. Alkahtani, Ghada E.A. Awad, Ahlam H. Mahmoud, Bassant M.M. Ibrahim, Ahmed Bari and Alexander Villinger.Synthesis and Evaluation of New Coumarin Derivatives as Antioxidant, Antimicrobial, and Anti-Inflammatory Agents. Molecules, MDPI, 2020.

M. Vetriselvan, D. Kalyanasundharam, N. Deepa and K. Babu, A Studies about synthesis, characterization and antibacterial activities of newly synthesized coumarin derivatives, Journal of Chemical and Pharmaceutical Research, ISSN : 0975-7384, 2016, 8(8):1063-1065,

Abhishek Kumar, Pankaj Kumar, Prashant Nayak, D. S. Sandeep, Sneh Priya2, Jainey P. James and H. Shravya, Synthesis and Antimicrobial Activity of Some New Coumarin Incorporated Pyridine-3-carbonitrile Derivatives, Journal of Pharmaceutical Research International, ISSN: 2456-9119, 33(21A): 12-20, 2021.

Afia Saleem, Syed Majid Bukhari, Asma Zaidi, Umar Farooq, Majid Ali, Asma Khan, Sidra Khan, Kausar Hussain Shah, Adeem Mahmood, Farhan Ahmed Khan, Enzyme inhibition and antibacterial potential of 4 Hydroxycoumarin derivatives, Brazilian Journal of Pharmaceutical Sciences, 56: e18654, 2022.

Kumar S, Kaur A, Kaur B, Gupta VK and Gupta M, Synthesis, Spectral Studies and Antimicrobial Activity of Coumarin Derivatives, International Journal of Pharmacognosy & Chinese Medicine, ISSN: 2576-4772. VOLUME :5, 2021.

Khalid mohammed khan, zafar s. Saim, muhammad zarrar khan, zia-ullah, m. Iqbal, choudhary, alta-ur-rahman, shahnaz perveen, zahid h. Chohan and claudiu t. Supuran. Synthesis of coumarin derivatives with cytotoxic, antibacterial and antifungal activity, journal of enzyme inhibition and medicinal chemistry, august 2004 vol. 19 (4). Pp. 373-379.

Rakesh R. Chavan and Kallappa M. Hosamani, Microwave-assistedsynthesis, computational studies and antibacterial/ anti-inflammatory activities of compounds based on coumarin-pyrazole hybrid, Royal society of chemistry,2022.

Dana M Hussein, Sahar B Al-juboory and Ammar A. Razzak Mahmood Synthesis, Characterization and Antibacterial Evaluation with Computational Study of New Schiff Bases Derived from 7-Hydroxy-4-Methyl Coumarin, Oriental journal of chemistry, issn: 0970-020 x, 2017, vol. 33, no. (2).

Ismiyarto, Fida Hidayatul Rafi'ah, Novianita Rizky, Nor Basid Adiwibawa, Prasetya, Purbowatiningrum Ria Sarjono, Ngadiwiyana, Synthesis and antibacterial activity test of 3-(3-(4-hydroxy-3-methylphenyl) akriloil) coumarin compounds, 13th Joint Conference on Chemistry (13th JCC), IOP Conf. Ser.: Mater. Sci. Eng. 509 012055, 2019.

Indu Singh1 and Arun Kumar, synthesis and antimicrobial activity of new indolylcoumarin derivatives containing thiazolidinone moiety, International Journal of Drug Research and Technology,ISSN 2277 – 1506, 2014, Vol. 4 (3), 39-45.

Nadia H. Metwally, Galal H. Elgemeie and Fatma G. Fahmy, Green synthesis: Antimicrobial activity of novel benzothiazole-bearing coumarin derivatives and their fluorescence properties, Egypt. J. Chem. Vol. 65, No. 2 pp. 679 - 686 (2022).

Hasnah Osman, Samina Khan Yusufza, Mohammad Shaheen Khan, Basma M. Abd Razik, New thiazolyl-coumarin hybrids: Design, synthesis, characterization, X-ray crystal structure antibacterial and antiviral evaluation, Journal of Molecular Structure, 2018.

Amit Kumar and Sushil Kumar, Coumarin-Chalcone Hybrids for Biological Potentials: A Strategy of Molecular Hybridization for Drug Design, Int. J. Pharm. Sci. Rev. Res., 64(2), September - October 2020; Article No. 24, Pages: 146-151.

Mohsen K.A. Regal, Safa S. Shaban, Souad A and El-Metwally, Synthesis and antimicrobial activity of some new coumarin and dicoumarol derivatives. Journal of Heterocyclic Chemistry, 2020;1–11.


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