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Drugs Targeting Hydrocephalus: A Comprehensive Overview

Muralinath E., Pooja Devi, Prasanta Chbukdhara, Sanjib Borah, Kalyan C., Archana Jain, Guruprasad M.

Abstract


Hydrocephalus is a medical condition manifested by an abnormal accumulation of cerebro Spinal fluid (CSF) within the brain ventricles. This accumulation can result in an enhanced Intra cranial pressure, potentially causing damage to the brain tissue. While surgical interventions namely stunt placement or endoscopic third ventriculostomy are normal approaches to manage Hydrocephalus. Diuretics are drugs that increase an elimination of water and electrolysis by the kidneys. In the context of Hydrocephalus, Diuretics namely furosemide can assist in decreasing the production of cerebro Spinal fluid, thereby decreasing the overall volume, particularly with in the ventricles osmotic agents namely mannitol and hypertonic saline perform by drawing excess fluid out of brain tissues, assisting in decreasing intra cranial pressure. Mannitol, for example, performs by the osmotic pressure of the blood, making fluid to move from the brain tissues into the blood stream, thereby relieving pressure.


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References


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