Therapeutic Approaches: Drugs Targeting Cervical Cancer

Abstract

Cervical cancer is a global health concern, with  human papilloma  virus ( HPV ) infection  being a promised risk factor for it's development.   Cisplatin is a platinum _ based drug generally  helpful for treating cervical cancer.  Thus drug  performsvby interfering with the DNA in cancer cells, stopping their ability to divide and replicate.    Cisplantin shows its efficacy  in both early ans advanced stages regarding  cervical cancer. Used in combination  with cisplantin, Paclitaxel increases  the effectiveness  of chemotherapy  regarding  treatment  of cervical  cancer. It's mechanisms  of action  disrupts the cancer cell cycle,  shopping  growth  as well as enhancing  cell death.  Bevacizumab is a mono clonal antibody  that targets vascular endothelial  growth factor ( VEGF ) , a  protein participated  on angio genesis  ( formation of new blood bessels).  By inhibiting  VEGF, bevacizumabdistpts blood supply to the tumor, restricting  it's growth.  Pembrolizuman is an immune checkpoint inhibitor that targets  the programmed cell death  protein  1 ( PD_ 1 ) pathway.  By inhibiting  PD_ 1, pembrolizumab increases the body's immune response against cancer cells.  Topotecan  is a topo isomerase inhibitor that interferes with DNA replication  and repair.  Regarding  the treatment  of recurrent cervical cancer, topotecan disrupts cancer cell. DNA, resulting  in cell death.an administration  of Topotecan occurs via intra venous route and can be an option for patients  who have relapsed after initial  treatments. Finally  it it is concluded that an advancements  in cancer research have led to the development  of diverse drugs targeting cervical cancer,  each with unique mechanism of action.