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DESIGN AND IVIVC OF LAMIVUDINE TRANSDERMAL PATCHES
Abstract
The transdermal drug delivery system for lamivudine was created utilising the solvent casting method with Span-80 acting as a permeation enhancer. The drug: polymer ratios (Lamivudine: HPMC and Lamivudine: EC) were created in two different ways: one at a ratio of 1:2.5, one at a ratio of 1:5, and one with permeation enhancers. The transdermal patch that was developed had good physical and chemical characteristics, did not cause any skin irritation in the rat skin, and was used in an in vitro drug permeation investigation where the rat skin was kept in phosphate buffer pH 7.4 for a full day. ANOVA's comparative statistical analytical data revealed a 'p' value of less than 0.0001, indicating the high significance of the produced formulation for transdermal distribution. The formulation (FPE2) ratio 1:5 of the patch containing a permeation enhancer and lamivudine: HPMC had the best outcome of all the formulations.
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