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Assessment of Some Oxidative Stress Biomarkers in Menopausal and Non-Menopausal Adult Female, in Edo State, Nigeria

Edebiri O. E., Akpe P. E., Akpotaire, P. A, Oviosun Augustine, Abudu, I. E, Ikhajiangbe, H. I., Onokevbagbe E. I

Abstract


Menopause is the permanent cessation of menses for 12 months resulting from estrogen deficiency and is not associated with pathology. The aim was to determine some oxidative stress biomarkers in Menopausal and non-menopausal adult female, in Edo state, Nigeria. The study involved twenty (20) consenting adult female participants, including 10 postmenopausal women and 10 non-menopausal women, recruited from Ekpoma metropolitan, Edo State. The study was conducted for three (3) months at Ambrose Alli University Ekpoma, Edo State Nigeria. Fasting blood samples were collected from all participants to measure oxidative stress biomarkers, including catalase, superoxide dismutase (SOD), and glutathione peroxidase (GPx) and were done spectrophotometrically. The result reveals that the mean values of non-menopausal and menopausal groups are 3.389 and 7.509 respectively, while the standard error of mean (SEM) was found to be 0.4252. The result revealed that there was a statistically significant difference (at P < 0.05) in the mean values of glutathione peroxidase activity between the menopausal and non-menopausal adult females. The mean values of non-menopausal and menopausal groups are 0.201 and 0.424 respectively, while the standard error of mean (SEM) was found to be 0.0199. The result revealed that there was a statistically significant difference (at P < 0.05) in the mean values of Superoxide dismutase activity between the menopausal and non-menopausal adult females. The mean values of non-menopausal and menopausal groups are 31.82 and 84.99 respectively, while the standard error of mean (SEM) was found to be 2.013. The result revealed that there was a statistically significant difference (at P < 0.05) in the mean values of catalase activity between the menopausal and non-menopausal adult females. Conclusively, at the end of this current study, the following were established; the level of glutathione peroxidase activity in both menopausal and non-menopausal adult was known and compared, that there was a statistically significantly difference in the catalase activity between menopausal and non-menopausal adult female.


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