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Advances in the Oral Delivery of Biologics

Patil Vaibhav Mahendra, Sameer R. Shaikh, Azam Z. Shaikh, Divakar R. Patil, Akash S. Jain

Abstract


The physiological hurdles to oral biologic distribution are discussed in the essay, with a focus on less well-studied barriers such the basement membrane. Next, recent developments in oral biologic administration using Nano medicine are discussed. Lastly, a discussion of the recently developed field of device-mediated gastrointestinal biotherapeutic administration is had.


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Eek, D., Krohe, M., Mazar, I., Horsfield, A., Pompilus, F., Friebe, R., & Shields, A. L. (2016). Patient-reported preferences for oral versus intravenous administration for the treatment of cancer: a review of the literature. Patient preference and adherence, 1609-1621.

Eek, D., Krohe, M., Mazar, I., Horsfield, A., Pompilus, F., Friebe, R., & Shields, A. L. (2016). Patient-reported preferences for oral versus intravenous administration for the treatment of cancer: a review of the literature. Patient preference and adherence, 1609-1621..

Vllasaliu, D., Casettari, L., Fowler, R., Exposito-Harris, R., Garnett, M., Illum, L., & Stolnik, S. (2012). Absorption-promoting effects of chitosan in airway and intestinal cell lines: a comparative study. International journal of pharmaceutics, 430(1-2), 151-160.

Bernkop-Schnürch, A. (2005). Mucoadhesive systems in oral drug delivery. Drug discovery today: Technologies, 2(1), 83-87.

Florence, A. T. (1997). The oral absorption of micro-and nanoparticulates: neither exceptional nor unusual. Pharmaceutical research, 14, 259-266.

Lundquist, P., & Artursson, P. (2016). Oral absorption of peptides and nanoparticles across the human intestine: Opportunities, limitations and studies in human tissues. Advanced drug delivery reviews, 106, 256-276.

Timpl, R., & Brown, J. C. (1996). Supramolecular assembly of basement membranes. Bioessays, 18(2), 123-132.

Mestres, P., Gomez, L. L., Lopez, T. N., del Rosario, G., Lukas, S. W., & Hartmann, U. (2014). The basement membrane of the isolated rat colonic mucosa. A light, electron and atomic force microscopy study. Annals of Anatomy-Anatomischer Anzeiger, 196(2-3), 108-118.

Nordisk, N. (2018). Novo Nordisk successfully completes the first phase 3a trial, PIONEER 1, with oral semaglutide. Novo Nordisk.

Verma, A., Sharma, S., Gupta, P. K., Singh, A., Teja, B. V., Dwivedi, P., ... & Mishra, P. R. (2016). Vitamin B12 functionalized layer by layer calcium phosphate nanoparticles: A mucoadhesive and pH responsive carrier for improved oral delivery of insulin. Acta biomaterialia, 31, 288-300.

Lai, S. K., O'Hanlon, D. E., Harrold, S., Man, S. T., Wang, Y. Y., Cone, R., & Hanes, J. (2007). Rapid transport of large polymeric nanoparticles in fresh undiluted human mucus. Proceedings of the National Academy of Sciences, 104(5), 1482-1487.

(2007). Nanoparticles in fresh undiluted human mucus. Proc Natl Acad Sci U S A. 30, 104(5), 14

Rossi, S., Vigani, B., Sandri, G., Bonferoni, M. C., Caramella, C. M., & Ferrari, F. (2019). Recent advances in the mucus-interacting approach for vaginal drug delivery: From mucoadhesive to mucus-penetrating nanoparticles. Expert Opinion on Drug Delivery, 16(8), 777-781.

Abramson, A., Caffarel-Salvador, E., Khang, M., Dellal, D., Silverstein, D., Gao, Y., ... & Traverso, G. (2019). An ingestible self-orienting system for oral delivery of macromolecules. Science, 363(6427), 611-615.

Crowe, J. S., Roberts, K. J., Carlton, T. M., Maggiore, L., Cubitt, M. F., Clare, S., ... & West, M. R. (2018). Preclinical development of a novel, orally-administered anti-tumour necrosis factor domain antibody for the treatment of inflammatory bowel disease. Scientific reports, 8(1), 4941.

Bernkop-Schnürch, A. (2005). Mucoadhesive systems in oral drug delivery. Drug discovery today: Technologies, 2(1), 83-87.

McCartney, F., Gleeson, J. P., & Brayden, D. J. (2016). Safety concerns over the use of intestinal permeation enhancers: A mini-review. Tissue barriers, 4(2), e1176822.

Mühlberg, E., Burtscher, M., Umstätter, F., Fricker, G., Mier, W., & Uhl, P. (2021). Trends in liposomal nanocarrier strategies for the oral delivery of biologics. Nanomedicine, 16(20), 1813-1832.

Andretto, V., Rosso, A., Briançon, S., & Lollo, G. (2021). Nanocomposite systems for precise oral delivery of drugs and biologics. Drug delivery and translational research, 11, 445-470.


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