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Exploring Pharmacotherapy for Blood Vessel Disorders

Muralinath E., Pooja Devi, Nikhil Ch. Nath, Champak B., Kalyan C., Archana Jain, Guruprasad M.

Abstract


Blood vessel disorders impact arteries, veins and capillaries and pose especially significant challenges. These disorders can result in complications namely atherosclerosis, hypertension and thrombosis. To regulate blood pressure, doctors usually prescribe antihypertensive drugs such as diuretics, ACE inhibitors, and calcium channel blockers. These drugs perform by relaxing blood vessels, decreasing vfluid volume or interfering with certain signalling pathways to maintain optimal blood pressure. Anti platelet drugs namely aspirin and clopidogrel stop platelet aggregation and prevent the formation 9f harmful blood clots and decrease the likelihood of vessel occlusion. Statins are lipid_ lowering drugs that decrease cholesterol, especially low_ density lipoprotein (LDL) cholesterol. Vasodilator medications namely hydrazine and nitroglycerin perform by widening blood vessels. This dilation increases blood flood decrease the workload on the heart, causing them valuable to manage conditions namely angina pectoris and heart failure. These drugs act in a direct manner on the smooth muscle cells particularly in blood vessel walls, resulting in relaxation and expansion of vessels. Anti coagulant medications like heparin and warfarin interfere with the blood clotting process obstructing the formation of abnormal clots. These drugs are critical in conditions namely deep vein thrombosis and pulmonary embolism, where abnormal clotting exhibits severe consequences. Angiotensin receptor blockers (ARBs) are used regarding management of hypertension and other cardio vascular conditions. In the end, it is determined that medication therapy plays a significant part in controlling and averting consequences related to blood vessel abnormalities.


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References


Loh, Y. C., Tan, C. S., Ch’ng, Y. S., Ahmad, M., Asmawi, M. Z., & Yam, M. F. (2016). Overview of antagonists used for determining the mechanisms of action employed by potential vasodilators with their suggested signaling pathways. Molecules, 21(4), 495.

Zsotér, T. T. (1983). Vasodilators. Canadian Medical Association Journal, 129(5), 424.

Tarkin, J. M., & Kaski, J. C. (2016). Vasodilator therapy: nitrates and nicorandil. Cardiovascular drugs and therapy, 30, 367-378.

Riegger, A. J. (1989). ACE inhibitors in congestive heart failure. Cardiology, 76(Suppl 2), 42-49.

Hammer, G. B., Lewandowski, A., Drover, D. R., Rosen, D. A., Cohane, C., Anand, R., ... & Schulman, S. R. (2015). Safety and efficacy of sodium nitroprusside during prolonged infusion in pediatric patients. Pediatric Critical Care Medicine, 16(5), 397-403.

Heer, T., Reiter, S., Trißler, M., Höfling, B., von Knobelsdorff‐Brenkenhoff, F., & Pilz, G. (2017). Effect of nitroglycerin on the performance of MR coronary angiography. Journal of Magnetic Resonance Imaging, 45(5), 1419-1428.

Regulski, M., Regulska, K., J Stanisz, B., Murias, M., Gieremek, P., Wzgarda, A., & Niznik, B. (2015). Chemistry and pharmacology of Angiotensin-converting enzyme inhibitors. Current pharmaceutical design, 21(13), 1764-1775.

Kuoppala, J., Enlund, H., Pulkkinen, J., Kastarinen, H., Jyrkkä, J., Happonen, P., & Paajanen, H. (2017). ACE inhibitors and the risk of acute pancreatitis—a population‐based case–control study. Pharmacoepidemiology and Drug Safety, 26(7), 853-857.

Raebel, M. A. (2012). Hyperkalemia associated with use of angiotensin‐converting enzyme inhibitors and angiotensin receptor blockers. Cardiovascular therapeutics, 30(3), e156-e166.10.

Livada, R., & Shiloah, J. (2014). Calcium channel blocker-induced gingival enlargement. Journal of human hypertension, 28(1), 10-14.


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