

An Objectives, Epidemiology, Diagnosis, Differential Diagnosis, Treatment, Prognosis, Complications and Health Care Team Outcomes of Seizures
Abstract
Uncontrolled, aberrant brain electrical activity that can cause changes in behavior, memory, emotions, or awareness is explained by a seizure. It is possible to differentiate between convulsive concussion, convulsive syncope, movement disorders, rigors, sleep-related events, or psychogenic non-epileptic episodes from an event. One can classify seizures as either partial or generalized. One region of the brain fires first during a partial seizure, which is the most common type of seizure in adults. Simple symptoms, such as motor or sensory abnormalities, may be present. Diffusing cortical activation during seizure initiation or generalization of partial seizure activity are the results of generalized seizures. The diagnosis and treatment of seizures are described in this activity, along with the function of the interprofessional team in improving patient outcomes. This exercise looks at how to properly diagnose this ailment and whether it should be taken into account when making a differential diagnosis. This exercise emphasizes how important the interprofessional team is to treat people with this illness.
References
Huff, J. S., Melnick, E. R., Tomaszewski, C. A., Thiessen, M. E., Jagoda, A. S., Fesmire, F. M., & American College of Emergency Physicians. (2014). Clinical policy: Critical issues in the evaluation and management of adult patients presenting to the emergency department with seizures. Annals of Emergency Medicine, 63(4), 437–447.e15. https://doi.org/10.1016/j.annemergmed.2014.01.018
Fisher, R. S., Acevedo, C., Arzimanoglou, A., Bogacz, A., Cross, J. H., Elger, C. E., Engel, J., Forsgren, L., French, J. A., Glynn, M., Hesdorffer, D. C., Lee, B. I., Mathern, G. W., Moshé, S. L., Perucca, E., Scheffer, I. E., Tomson, T., Watanabe, M., & Wiebe, S. [ILAE official report: A practical clinical definition of epilepsy. Epilepsia, 55(4), 475–482. https://doi.org/10.1111/epi.12550
Huff, J. S., & Fountain, N. B. (2011). Pathophysiology and definitions of seizures and status epilepticus. Emergency Medicine Clinics of North America, 29(1), 1–13. https://doi.org/10.1016/j.emc.2010.08.004
Lowenstein, D. H., Bleck, T., & Macdonald, R. L. (1999). It's time to revise the definition of status epilepticus. Epilepsia, 40(1), 120–122. https://doi.org/10.1111/j.1528-1157.1999.tb02000.x
Lowenstein, D. H., & Alldredge, B. K. (1993). Status epilepticus at an urban public hospital in the 1980s. Neurology, 43(3 Pt 1), 483–488. https://doi.org/10.1212/wnl.43.3_part_1.483
Banerjee, P. N., Filippi, D., & Hauser, W. A. (2009). The descriptive epidemiology of epilepsy–A review. Epilepsy Research, 85(1), 31–45. https://doi.org/10.1016/j.eplepsyres.2009.03.003
Sen, A., Jette, N., Husain, M., & Sander, J. W. (2020). Epilepsy in older people. The Lancet, 395(10225), 735–748. https://doi.org/10.1016/S0140-6736(19)33065-0
Orringer, C. E., Eustace, J. C., Wunsch, C. D., & Gardner, L. B. (1977). Natural history of lactic acidosis after grand-mal seizures. New England Journal of Medicine, 297(15), 796–799. https://doi.org/10.1056/NEJM197710132971504
Simon, R. P. (1985). Physiologic consequences of status epilepticus. Epilepsia, 26(s1), S58–S66. https://doi.org/10.1111/j.1528-1157.1985.tb05753.x
Chen, J. W., & Wasterlain, C. G. (2006). Status epilepticus: Pathophysiology and management in adults. The Lancet Neurology, 5(3), 246–256. https://doi.org/10.1016/S1474-4422(06)70374-X
Fountain, N. B., & Lothman, E. W. (1995). Pathophysiology of status epilepticus. Journal of Clinical Neurophysiology, 12(4), 326–342. https://doi.org/10.1097/00004691-199507000-00004
Treiman, D. M., Walton, N. Y., & Kendrick, C. (1990). A progressive sequence of electroencephalographic changes during generalized convulsive status epilepticus. Epilepsy Research, 5(1), 49–60. https://doi.org/10.1016/0920-1211(90)90044-F
Trinka, E., Cock, H., Hesdorffer, D., Rossetti, A. O., Scheffer, I. E., Shinnar, S., Shorvon, S., & Lowenstein, D. H. (2015). A definition and classification of status epilepticus–Report of the ILAE Task Force on Classification of Status Epilepticus. Epilepsia, 56(10), 1515–1523. https://doi.org/10.1111/epi.13121
Harden, C. L., Huff, J. S., Schwartz, T. H., Dubinsky, R. M., Zimmerman, R. D., Weinstein, S., Foltin, J. C., Theodore, W. H., & Therapeutics and Technology Assessment Subcommittee of the AAN. (2007). Reassessment: Neuroimaging in the emergency patient presenting with seizure. Neurology, 69(18), 1772–1780. https://doi.org/10.1212/01.wnl.0000286944.15759.b6
American College of Emergency Physicians, American Academy of Neurology, American Association of Neurological Surgeons, & American Society of Neuroradiology. (1996). Practice parameter: Neuroimaging in the emergency patient presenting with seizure (summary statement). Annals of Emergency Medicine, 28(1), 114–118. https://doi.org/10.1016/s0196-0644(96)70061-3
D'Onofrio, G., Rathlev, N. K., Ulrich, A. S., Fish, S. S., & Freedland, E. S. (1999). Lorazepam for the prevention of recurrent seizures related to alcohol. New England Journal of Medicine, 340(12), 915–919. https://doi.org/10.1056/NEJM199903253401203
Brophy, G. M., Bell, R., Claassen, J., Alldredge, B., Bleck, T. P., Glauser, T., Laroche, S. M., Riviello, J. J., Shutter, L., Sperling, M. R., Treiman, D. M., Vespa, P. M., & Neurocritical Care Society Status Epilepticus Guideline Writing Committee. (2012). Guidelines for the evaluation and management of status epilepticus. Neurocritical Care, 17(1), 3–23. https://doi.org/10.1007/s12028-012-9695-z
Claassen, J., Riviello, J. J., & Silbergleit, R. (2015). Emergency Neurological Life Support: Status epilepticus. Neurocritical Care, 23(Suppl 2), S136–S142. https://doi.org/10.1007/s12028-015-0180-2
Sathe, A. G., Tillman, H., Coles, L. D., Elm, J. J., Silbergleit, R., Chamberlain, J., Kapur, J., Cock, H. R., Fountain, N. B., Shinnar, S., Lowenstein, D. H., Conwit, R. A., Bleck, T. P., & Cloyd, J. C. (2019). Underdosing of benzodiazepines in patients with status epilepticus. Academic Emergency Medicine, 26(8), 940–943. https://doi.org/10.1111/acem.13762
Kapur, J., Elm, J., Chamberlain, J. M., Barsan, W., Cloyd, J., Lowenstein, D., Shinnar, S., Conwit, R., Meinzer, C., Cock, H., Fountain, N., Connor, J. T., Silbergleit, R., & NETT and PECARN Investigators. (2019). Randomized trial of three anticonvulsant medications for status epilepticus. New England Journal of Medicine, 381(22), 2103–2113. https://doi.org/10.1056/NEJMoa1905795
Hantus, S. (2016). Epilepsy emergencies. Continuum (Minneap Minn), 22(1 Epilepsy), 173–190. https://doi.org/10.1212/CON.0000000000000260
Welch, R. D., Nicholas, K., Durkalski-Mauldin, V. L., Lowenstein, D. H., Conwit, R., Mahajan, P. V., Lewandowski, C., Silbergleit, R., & NETT Network Investigators. (2015). Intramuscular midazolam versus intravenous lorazepam for the prehospital treatment of status epilepticus in the pediatric population. Epilepsia, 56(2), 254–262. https://doi.org/10.1111/epi.12916
Silbergleit, R., Durkalski, V., Lowenstein, D., Conwit, R., Pancioli, A., Palesch, Y., Barsan, W., & NETT Investigators. (2012). Intramuscular versus intravenous therapy for prehospital status epilepticus. New England Journal of Medicine, 366(7), 591–600. https://doi.org/10.1056/NEJMoa1107494
Betjemann, J. P., & Lowenstein, D. H. (2015). Status epilepticus in adults. The Lancet Neurology, 14(6), 615–624. https://doi.org/10.1016/S1474-4422(15)00042-3
Lin, J. T., Ziegler, D. K., Lai, C. W., & Bayer, W. (1982). Convulsive syncope in blood donors. Annals of Neurology, 11(5), 525–528. https://doi.org/10.1002/ana.410110510
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