A review of dietary supplementation with L-arginine in the management of hypertension

Abstract

An amino acid is the basic chemical that serves as a protein building block. A protein is made up of one or more chains of amino acids (called polypeptides) that are encoded in a gene. Some amino acids are synthesised in the body,they arealanine, arginine, asparagine, aspartic acid, cysteine, glutamic acid, glutamine, glycine, proline, serine, and tyrosine.. L-arginine is one of several amino acids required by the body to function effectively. L-arginine, like other amino acids, helps for protein synthesis. Protein is used by the body to help build muscle and repair tissue. It transforms this amino acid into the molecule nitric oxide, which aids in the opening of blood vessels. L-arginine has been studied for its effectiveness in treating high blood pressure and chest pain. Endothelial dysfunction and reduced nitric oxide (NO) bioactivity represent prominent pathophysiological abnormalities associated with hypertensive cardiovascular disease. As we know Hypertension, often known as high or an increase of blood pressure, is a condition characterised by chronically elevated blood vessel pressure. Hypertension is a chronic condition that affects over 972 million people worldwide and 188.3 million people in India. High blood pressure is estimated to cause 7.5 million death worldwide, accounting for around 12.8% of all deaths. In this papers we are focusing on dietary supplements of L -arginine in the treatment of hypertension.