Drugs Affecting Uterine Motility: Understanding Their Mechanisms and Clinical Implications

Abstract

The regulation of uterine motility plays a major role specifically in many physiological processes, along with menstruation, pregnancy and childbirth, Oxytocin is involved in causing uterine contractions particularly during labor. Regarding clinical point of view, Oxytocin is frequently administered intravenously to induce or argument labor, controls post partum hemorrhage and especially helps in the expulsion of the placenta. Beta_ adrenergic agonists such as terbutaline and ritodtmrine interact with beta _ adrenergic receptors regarding uterine smooth muscles. Calcium channel blocker namely nifedipine interacts with Calcium influx into the uterine smooth muscle cells, decreasing contractions. This type of drugs is useful as tocolytics in suppressing pre mature contractions specifically in case of preterm labor. Prostaglandins namely misiprostol and dinoprostone play a major role in initiating and enhancing uterine contractions. Magnesium sulphate influences uterine contractility by interfering with calcium entry into smooth muscle cells. Finally it is concluded that understanding the mechanisms of drugs acting on uterine motility is responsible for clinicians managing various reproductive health conditions.