DRUGS ACTING ON GOUT AND DRUGS TARGETING ACID METABOLISM

Abstract

Gout occurs due to the accumulation of uric acid crystals particularly in the joints and results in discomfort, pain and swelling. Non steroidal anti _ inflammatimiry drugs ( NSAID) Research involved for the management of a ute gout attacks. Indomethacin and naproxen decrease pain and decrease inflammation by stopping the production of inflammatory compounds. Colchicine shows its activity regarding treatment of acute gout attacks by decreasing inflammation and decreasrsthe movement of leukocytes to the affected joint. Colchine leads to the occurrence of side effects. Sometimes corticosteroids are administered orally or injected into the affected joint to decreasevpain and inflammation. Allopurinol, febuxodtat and xanthine inhibitors decrease uric acid levels by stopping this enzyme. Uricosuric agents namely probenecid perform by enhancing the excretion of uric acid through the kidneys. Lesinurad is useful regarding gout inhibitor, primarily targeting the URAT _1 transporter in the kidneys.  Pegloticase is an enzyme replacement therapy that breakdown uric acid into a more soluble form. it is finally concluded that medications impacting uric acids metabolism, namely xanthine oxidase inhibitors. Uricosuric agents and other drugs such as lesinurad and pegloiicase ply a critical role in regulating gout symptoms and stopping prevent attacks