The Impact of Drugs on Angina Pectoris: A Comprehensive Analysis
Abstract
Angina pectoris is a cardio vascular condition manifested by chest pain or discomfort occurred by reduced blood flow to the heart muscle. Nitro glycerin also dilates coronary arteries and increases blood flow to the heart muscle. Vasodilators relaxes blood vessels and decreases hearts workload. Beta blockers decrease oxygen demand and stop angina episodes.
Antiplatlet agents are frequently used for individuals withvangina . Aspirin stops the aggregation of platelets and decreases the risk of blood clot formation and subsequent vmyocardial infarction. Clopidogrel is used only with aspirin for enhanced efficacy. Statins decrease angina by lowering cholesterol leves in the blood. Angiotensin_ converting enzyme (ACE) inhibit and angiotensin II receptor blockers ( ARBs ) are used to treat hypertension of heart failure. These drugs dilate the blood vessels and decrease the workload on the heart and contribute to the management of angina symptoms. Ranazoline performs by inhibiting sodium channels in the heart and decrease intra cellular calcium and consequently myocardial oxygen demand. Finally it is concluded that the pharmacological management of angina pectoris involves a variety of drugs targeting various aspects of cardio vascular system.
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Balla C, Pavasini R, Ferrari R. Treatment of Angina: Where Are We? Cardiology. 2018;140(1):52-67. [PubMed]
Ferrari R, Camici PG, Crea F, Danchin N, Fox K, Maggioni AP, Manolis AJ, Marzilli M, Rosano GMC, Lopez-Sendon JL. Expert consensus document: A ‘diamond’ approach to personalized treatment of angina. Nat Rev Cardiol. 2018 Feb;15(2):120-132. [PubMed]
Picard F, Sayah N, Spagnoli V, Adjedj J, Varenne O. Vasospastic angina: A literature review of current evidence. Arch Cardiovasc Dis. 2019 Jan;112(1):44-55. [PubMed]
Wolk R, Berger P, Lennon RJ, Brilakis ES, Somers VK. Body mass index: a risk factor for unstable angina and myocardial infarction in patients with angiographically confirmed coronary artery disease. Circulation. 2003 Nov 04;108(18):2206-11. [PubMed]
Mancini GB, Gosselin G, Chow B, Kostuk W, Stone J, Yvorchuk KJ, Abramson BL, Cartier R, Huckell V, Tardif JC, Connelly K, Ducas J, Farkouh ME, Gupta M, Juneau M, O’Neill B, Raggi P, Teo K, Verma S, Zimmermann R., Canadian Cardiovascular Society. Canadian Cardiovascular Society guidelines for the diagnosis and management of stable ischemic heart disease. Can J Cardiol. 2014 Aug;30(8):837-49. [PubMed]
Wee Y, Burns K, Bett N. Medical management of chronic stable angina. Aust Prescr. 2015 Aug;38(4):131-6. [PMC free article] [PubMed]
Boden WE, O’Rourke RA, Teo KK, Hartigan PM, Maron DJ, Kostuk WJ, Knudtson M, Dada M, Casperson P, Harris CL, Chaitman BR, Shaw L, Gosselin G, Nawaz S, Title LM, Gau G, Blaustein AS, Booth DC, Bates ER, Spertus JA, Berman DS, Mancini GB, Weintraub WS., COURAGE Trial Research Group. Optimal medical therapy with or without PCI for stable coronary disease. N Engl J Med. 2007 Apr 12;356(15):1503-16. [PubMed]
Rayner-Hartley E, Sedlak T. Ranolazine: A Contemporary Review. J Am Heart Assoc. 2016 Mar 15;5(3):e003196. [PMC free article] [PubMed]
Silva FM, Pesaro AE, Franken M, Wajngarten M. Acute management of unstable angina and non-ST segment elevation myocardial infarction. Einstein (Sao Paulo). 2015 Jul-Sep;13(3):454-61. [PMC free article] [PubMed]
Yusuf S, Zhao F, Mehta SR, Chrolavicius S, Tognoni G, Fox KK., Clopidogrel in Unstable Angina to Prevent Recurrent Events Trial Investigators. Effects of clopidogrel in addition to aspirin in patients with acute coronary syndromes without ST-segment elevation. N Engl J Med. 2001 Aug 16;345(7):494-502. [PubMed]
Hjemdahl P, Eriksson SV, Held C, Forslund L, Näsman P, Rehnqvist N. Favourable long term prognosis in stable angina pectoris: an extended follow up of the angina prognosis study in Stockholm (APSIS). Heart. 2006 Feb;92(2):177-82. [PMC free article] [PubMed]
Hemingway H, McCallum A, Shipley M, Manderbacka K, Martikainen P, Keskimäki I. Incidence and prognostic implications of stable angina pectoris among women and men. JAMA. 2006 Mar 22;295(12):1404-11. [PubMed]
Kloner RA, Chaitman B. Angina and Its Management. J Cardiovasc Pharmacol Ther. 2017 May;22(3):199-209. [PubMed]
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