Open Access Open Access  Restricted Access Subscription Access

The Complex Relationship between Drugs and Epileptic Patients: A Comprehensive Exploration

Muralinath E., Pooja Devi, Prasanta Chbukdhara, Sanjib Borah, Kalyan C., Archana Jain, Guruprasad M.

Abstract


Epilepsy is a neurological  disorder  manifested  by recurrent  seizures, influencing millions  of people  worldwide.  Anti epileptic  drugs ( AEDs) are treated as primary  treatment  for epilepsy.  Anti epileptic  drugs  show  their action  on various  targets  particularly  within the brain, namely  ion channels, neurological transmitter  system. Types of Anti epileptic  drugs include  calcium  channel  blockers, GABA enhancers, glutamate  receptor antagonist  and sodium  channel  blockers.  Side effects of AEDs  are dizziness  or drowsiness, life style factors  namely  sleep, stress management.  Some studies  indicate  that cannabidol ( CBD) may decrease  seizure frequency  particularly  in certain  types of epilepsy.  Finally it us concluded that health care professionals play a major  role in monitoring  and managing  drug interactions, educating  patients regarding potential  risks and. Providing  holistic care to address both seizure  control  and overall  health.


Full Text:

PDF

References


, Moges G, Demessie Y. Assessment of Patients’ Adherence to Antiepileptic Medications at Dessie Referral Hospital, Chronic Follow-Up, South Wollo, Amhara Region, North East Ethiopia. Neurol Res Int. 2018;2018:5109615. [PMC free article] [PubMed]

Kanner AM, Ashman E, Gloss D, Harden C, Bourgeois B, Bautista JF, Abou-Khalil B, Burakgazi-Dalkilic E, Park EL, Stern J, Hirtz D, Nespeca M, Gidal B, Faught E, French J. Practice guideline update summary: Efficacy and tolerability of the new antiepileptic drugs II: Treatment-resistant epilepsy: Report of the American Epilepsy Society and the Guideline Development, Dissemination, and Implementation Subcommittee of the American Academy of Neurology. Epilepsy Curr. 2018 Jul-Aug;18(4):269-278. [PMC free article] [PubMed]

Karceski S. Pregnancy, anti-seizure medications, and seizures. Neurology. 2018 Sep 25;91(13):e1271-e1274. [PubMed]

De Toffol B, Trimble M, Hesdorffer DC, Taylor L, Sachdev P, Clancy M, Adachi N, Bragatti JA, Mula M, Kanemoto K. Pharmacotherapy in patients with epilepsy and psychosis. Epilepsy Behav. 2018 Nov;88:54-60. [PubMed]

Nevitt SJ, Sudell M, Weston J, Tudur Smith C, Marson AG. Antiepileptic drug monotherapy for epilepsy: a network meta-analysis of individual participant data. Cochrane Database Syst Rev. 2017 Dec 15;12(12):CD011412. [PMC free article] [PubMed]

Devinsky O, Vezzani A, O’Brien TJ, Jette N, Scheffer IE, de Curtis M, Perucca P. Epilepsy. Nat Rev Dis Primers. 2018 May 03;4:18024. [PubMed]

Tian N, Boring M, Kobau R, Zack MM, Croft JB. Active Epilepsy and Seizure Control in Adults – United States, 2013 and 2015. MMWR Morb Mortal Wkly Rep. 2018 Apr 20;67(15):437-442. [PMC free article] [PubMed]

Dang LT, Silverstein FS. Drug Treatment of Seizures and Epilepsy in Newborns and Children. Pediatr Clin North Am. 2017 Dec;64(6):1291-1308. [PubMed]

O’Dwyer M, Peklar J, Mulryan N, McCallion P, McCarron M, Henman MC. Prevalence and patterns of anti-epileptic medication prescribing in the treatment of epilepsy in older adults with intellectual disabilities. J Intellect Disabil Res. 2018 Mar;62(3):245-261. [PubMed]

Johnson KA, Macfarlane MD, Looi JC. Affective disorders and functional (non-epileptic) seizures in persons with epilepsy. Australas Psychiatry. 2016 Dec;24(6):526-528. [PubMed]

DeToledo J. Pregnancy in epilepsy: issues of concern. Int Rev Neurobiol. 2008;83:169-80. [PubMed]

Tang MHY, Chong YK, Chan CY, Ching CK, Lai CK, Li YK, Mak TWL. Cluster of acute poisonings associated with an emerging ketamine analogue, 2-oxo-PCE. Forensic Sci Int. 2018 Sep;290:238-243. [PubMed]

Suddock JT, Kent KJ, Cain MD. StatPearls [Internet]. StatPearls Publishing; Treasure Island (FL): Apr 12, 2023. Barbiturate Toxicity. [PubMed]

Vidaurre J, Gedela S, Yarosz S. Antiepileptic Drugs and Liver Disease. Pediatr Neurol. 2017 Dec;77:23-36. [PubMed]

Giray S, Ozenli Y, Ozisik H, Karaca S, Aslaner U. Health-related quality of life of patients with epilepsy in Turkey. J Clin Neurosci. 2009 Dec;16(12):1582-7. [PubMed]

Hamed S, Mohamed K, El-Taher A, Hamed E, Omar H. The sexual and reproductive health in men with generalized epilepsy: a multidisciplinary evaluation. Int J Impot Res. 2006 May-Jun;18(3):287-95. [PubMed]

Sperling MR, Bucurescu G, Kim B. Epilepsy management. Issues in medical and surgical treatment. Postgrad Med. 1997 Jul;102(1):102-4, 109-12, 115-8 passim. [PubMed]


Refbacks

  • There are currently no refbacks.