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Exploring Drugs and Therapies Targeting Brain Injury Recovery

Muralinath E., Jayinder Paul Singh G., Pradip Kumar Das, Panjan Ghosh. P., Kinsuk Das S., Kalyan C., Archana Jain, Guruprasad M.

Abstract


Brain injuries can show profound and listing effects on an individual’s cognitive and physical abilities. Various drugs categorized as neuro protective agents have exhibited an influence in minimizing the initial damage occurred by brain injuries these agents frequently behave by decreasing inflammation, stopping excitotoxicity and preserving neuronal integrity. Examples are NMDA receptor antagonist such as mementine and anti-inflammatory drugs namely corticosteroids. Growth factors and neurotrophins play an important role particularly in activating the growth, survival and differentiation of neurons. Brain_ derived neurotoxin factor (BDNF) and nerve growth factor (NGF) are examples of substance that enhance neuronal health. Therapies involving the administration of these factors or the use of drugs that increase their activity are especially under investigation for their potential in supporting Brain injury recovery. Cognitive deficits frequently accompany Brain injuries and drugs targeting cognitive enhancement can be valuable regarding rehabilitation. Medications such as done penile, which are generally used in Alzheimers disease, have been explored for their potential to enhance memory and cognitive function particularly in individuals with brain Injuries. Brain injuries particularly those influencing motor areas, can result in muscle spasticity. Medications namely baclofen and tizanidine are generally prescribed to manage spasticity by acting on the central nervous system. These drugs can enhance mobility and decrease discomfort related to enhanced muscle tone in a very few cases, Brain injuries may lead to fatigue and reduced alertness. Psychostimulant Medications such as methyl phenidate have been investigated particularly for their ability to increase wakefulness and attention, potentially assisting regarding the recovery of cognitive function. Seizures are a general complication of traumatic brain injuries. Anti-epileptic Medications namely phenytoin and levetiracetam are generally used to stop and manage post_ traumatic seizures, which can exacerbate particularly Brain damage and hinder recovery. Finally it is concluded that the field of drugs and therapies targeting g Brain injury recovery is dynamic and evolving.


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