

Assessment of Relationship Between Genotype and Menstrual Flow Amongts Students of Ebonyi State University
Abstract
The findings from this study will provide valuable insights into the genetic and biological mechanisms influencing menstrual regulation. This can aid in medical diagnosis, genetic counseling, and the development of personalized medicine approaches for managing menstrual disorders, ultimately enhancing reproductive health and individual well-beign. The aim of the study is to assessed the relationship between genotype and menstrual flow amongts student of Ebonyi state University. 167apparently healthy female students of Ebonyi state university aged between 18-29years were selected for the study. Relevant information needed for this study such as ( duration of blood flow, duration of menstrual cycle, genotype etc) were collected using structured questionnaires.Data generated from the study was entered in Microsoft Excel spreadsheet and analyzed using SPSS version 23. To compare means of two independent groups, students’t-test for Independent samples was used. P value <0.05 were considered significant. From this present study, result reflects a consistent statistically significant increase (p<0.05) in the duration of menstrual cycle across the three different genotype groups (AA, AS and SS), those who fall within the range of 21-35days(AA-65.27±2.18,AS-23.95±1.77,SS-1.08±0.12) were higher, followed by those who experience theirs in<21days (AA-10.9±1.17,AS-4.00±0.99, SS-0.00) and finally those who experience theirs >35days (AA-2.45±1.11,AS-1.76±0.89,SS- 0.79±0.02) respectively.
References
Akhigbe, R. E., & Ige, S. F. (2009). Prevalence of sickle cell trait among adolescents in southwestern Nigeria. African Journal of Medical Sciences, 38(2), 161–163.
Alberts, B., Johnson, A., Lewis, J., Raff, M., Roberts, K., & Walter, P. (2021). Molecular biology of the cell (7th ed.). Garland Science.
Bakare, A. A., Adegoke, S. A., Ayinde, O. C., Adeyemo, T. A., & Akinsulie, A. O. (2006). Prevalence of sickle cell disease in Nigeria. African Journal of Medicine and Medical Sciences, 35(3), 275–279.
Boakye-Yiadom, A., Abdulai, F. T., Osei-Tutu, E., & Arko-Mensah, J. (2018). Role of parents in adolescent menstrual health education in developing countries. BMC Women’s Health, 18(1), 1-7.
Chandra-Mouli, V., & Patel, S. V. (2017). Mapping the knowledge and understanding of menarche and menstruation: A global review. Reproductive Health, 14(1), 1-18.
Fiekumo, T., & Charity, E. (2014). Prevalence and implications of abnormal hemoglobin genotypes in Nigeria. Journal of Health and Genetics, 12(3), 89–95.
Griffiths, A. J. F., Wessler, S. R., Carroll, S. B., & Doebley, J. (2020). Introduction to genetic analysis (12th ed.). W. H. Freeman.
Huisman, T. H. (1993). Levels of hemoglobin switching in humans. American Journal of Hematology, 42(3), 201–210.
Jeremiah, Z. A. (2006). Frequency of hemoglobinopathies in sickle cell patients in Port Harcourt, Nigeria. Pathology and Laboratory Medicine International, 2, 41–46.
Jeremiah, Z. A. (2006). Frequency of sickle cell disorders in African populations. African Health Journal, 10(1), 15–20.
Lukin, J. A., & Ho, C. (2004). Role of hemoglobin in oxygen transport. Journal of Biochemistry, 12(7), 56–62.
Macklon, N. S., & Fauser, B. C. (1999). Regulation of the menstrual cycle: A review. Human Reproduction Update, 5(5), 493–508.
Makani, J., et al. (2013). Hemoglobin variants and their implications in African populations. Blood, 121(21), 4163–4168.
Mihm, M., et al. (2011). Hormonal dynamics during the menstrual cycle. Reproductive Biology Insights, 4(1), 9–20.
Munro, M. G., Critchley, H. O. D., Broder, M. S., & Fraser, I. S. (2020). FIGO classification system (PALM-COEIN) for causes of abnormal uterine bleeding. International Journal of Gynecology & Obstetrics, 131(1), 3–13.
Onuoha, C. C., et al. (2015). Distribution of hemoglobin genotypes in Nigeria. Nigerian Journal of Hematology, 8(2), 45–49.
Pennap, G. R., Adoga, M. P., & Oyige, O. (2011). Prevalence of sickle cell disease in Nigeria. Journal of Hematology and Thromboembolic Diseases, 11(3), 271–278.
Quraishi, S. H., et al. (2015). Menstruation and its biological aspects. International Journal of Women’s Health, 7(1), 123–132.
Safo, M. K. (2011). Structural aspects of hemoglobin variants. Journal of Molecular Biology, 7(4), 89–92.
Soranzo, N. (2010). Hemoglobin variability and disease susceptibility. Nature Reviews Genetics, 11(6), 445–457.
Speroff, L., Fritz, M. A., & Seifer, D. B. (2019). Clinical gynecologic
endocrinology and infertility (9th ed.). Lippincott Williams & Wilkins.
Upashe, S. P., Tekelab, T., & Mekonnen, J. (2015). Assessment of knowledge and practices regarding menstrual hygiene among high school girls in developing countries. PLOS ONE, 10(4), e0125214.
Welt, C. K., et al. (2003). Regulation of menstrual cycle by hypothalamic-pituitary-gonadal axis. New England Journal of Medicine, 349(3), 274–283.
Worlledge, S., & Ogiemudia, S. (1974). Hemoglobinopathies in Nigeria. West African Journal of Medicine, 9(2), 34–39.
Yadav, S., Yadav, R. K., Jain, S., & Yadav, N. (2017). Knowledge and practices of menstrual hygiene among adolescent girls in developing countries. Journal of Clinical and Diagnostic Research, 11(1), LE01–LE04.
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