AN EXAMINATION OF THE MUCOADHESIVE DRUG DISTRIBUTION SYSTEM

Abstract

By creating innovative drug delivery methods, like the mucoadhesive system, medication effects can be improved.  Mucoadhesive drug delivery techniques interact with the mucus layer covering the mucosal surfaces. Mucin molecules and the epithelium surface, prolonging the duration the dose form spends at the absorption site. Drugs that have a local effect or that are best absorbed in the gastrointestinal tract (GIT) need to stay there for a longer period of time.There are now five theories that explain mucoadhesion: electronic, adsorption, wetting, diffusion, and fracture. The complex process of mucoadhesion involving a polymeric drug delivery system involves interactions between polymer chains through wetting, adsorption, and other mechanisms. Increased medication plasma concentrations and therapeutic activity are benefits of mucoadhesive dosage formulations. The physicochemical properties of the polymeric formulation and the kind of mucosal tissue are only two of the several factors that affect a dosage form's tendency to stick to mucous membranes.As a result, many mucosal-covered organelles utilise mucoadhesive systems extensively for the transfer of active substances for either local or systemic action. Drugs administered buccally have a number of advantages over those administered orally, including faster action and better patient compliance, especially for paediatric and geriatric patients. An overview of the various elements of mucoadhesion, mucoadhesive materials, factors affecting mucoadhesion, and lastly different mucoadhesive drug delivery systems are all part of this review paper.