Formulation Development of Caffeine Topical Gel with Natural Gelling Agents

Abstract

When applied to the skin, topical products containing caffeine may have anti-inflammatory properties. The anti-inflammatory properties of caffeine can assist in reducing skin redness, swelling, and inflammation. It is therefore ideal for treating skin that is irritated or sensitive. The formulation is based on caffeine, Carbopol, flaxseed, fenugreek and lemon oil. The caffeine as an active ingredient has anti-aging, anti-inflammatory and skin-softening properties. Carbopol is a non-irritating and non-toxic gelling chemical that is perfect for gel preparation. It functions well as a stabilizer as well. Gels with a 3%w/w caffeine content were made. The product was evaluated for organoleptic properties, pH, viscosity, spreadability , drug content and in vitro drug release study. Formulations with lower polymer concentration were not firm enough to be gels, while higher polymer concentration resulted in lower spread ability and drug release.