Phagocytic Activity and Hexose Monophosphate Shunt activity of cultured human Kupffer cells upon zymosan, erythrocytes, amoebic trophozoits, latex beads and nitroimidazole

Abstract

Background: Isolated human Kupffer cells defend the parenchymal hepatocytes from parasite infection or presence of foreign additives in cultured liver cells. Aim: Nitroimidazole acts as antiparasitic drug to defend the isolated liver cells by the phagocytic action of Kupffer cells. Results: The Kupffer cells showed high phagocytic activity in presence of amoebic trophozoits that was minimized in the presence of nitroimidazole. Kupffer cells showed phagocytic function as uptake of zymosan particles larger than 1 micron size and no action on inert latex particles. The endothelial cells act as phagocytes in phagocytosis as second line of defense in liver. Kupffer cells engulf the beads, amoebic trophozoits, and removed foreign additives keeping themselves intact. The first Kupffer cell and trophozoits interaction in the presence of nitroimidazole suggested the synergistic interaction and this cellular interaction may be taken into account for any drug stimulated quantitative phagocytosis analysis in liver.

Cite as

Rakesh Sharma, & Vijay S. Singh. (2023). Phagocytic Activity and Hexose Monophosphate Shunt Activity of Cultured Human Kupffer Cells upon Zymosan, Erythrocytes, Amoebic Trophozoits, Latex Beads and Nitroimidazole. Journal of Advances in Nanotechnology and Its Applications, 5(1), 7–17. https://doi.org/10.5281/zenodo.7836088