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Exploring Endothelial Progenitor Cells (EPCs): Key Players in Vascular Development
Abstract
Endothelial progenitor cells play an important role in vascular development, repair as well as regeneration. These cells, e hi it remarkable abilities to contribute to the formation and maintenance of blood vessels throughout the body. The derivation of EPCs takes from hemopoietic stem cells especially in the bone marrow. They are manifested by their capacity to differentiate particularly into mature Endothelial cells, the building blocks of blood vessels. Additionally , EPCs exhibit unique surface markers namely CD 34. CD 133 and vascular endothelial growth factor receptor 2 ( VEGFR_2 ) which distinguish them from other cell types. During embryogenesis, EPCs show the participation in angiogenesis, the process of new blood vessel formation. They migrate to sites of vascular injury or ischemua, where they migrate into existing vessels or contribute to the formation of new capillaries. This process is responsible for tissue repair and regeneration, particularly on response to conditions namely myocardial infarction or stroke. The mobilization of EPCs from the bone marrow into circulation is regulated in a tight manner by many factors such as cytokines, growth factors and chemokines. A very few factors such as hypoxia and physical exercise have been shown to enhance EP mobilization highlighting the complex regulatory mechanisms involved. Finally it is concluded that endothelial progenitor cells represent a promising Venue for promoting vascular development and repair.
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