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Analysis of different types of Haemoglobinopathies in Anaemic Children High performance Liquid Chromatography

Dr. Snehlata, Dr. Ranjan Agrawal, Dr. Prashant Bharadwaj, Dr. Prateek Sharma

Abstract


Among the most prevalent inherited single-gene illnesses worldwide, hemoglobinopathies—including β-thalassemia, sickle cell disease, HbE, and other structural variants are especially responsible for anaemia in paediatric populations in South Asia and India. For children, an early and precise diagnosis is essential to preventing morbidity and facilitating prompt care. When evaluating paediatric anaemia, HPLC should be combined with peripheral smear examination, full blood counts, and family studies. Its use as a primary diagnostic technique in prenatal, paediatric, and premarital screening programs particularly in areas with high prevalence can greatly increase the rate of early identification, direct genetic counselling, and lessen the burden of severe hemoglobinopathy in subsequent generations.


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References


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