Ameliorating Effects of Ethanoic Extract of Ripe and unripe Banana Fruits in Salt Loaded, Alcoholic and Indomethacin Induced Ulcerative Rats

Abstract

Ripe and unripe Banana is used in southeast Nigeria as a bland diet for peptic ulcer patients. Flour made of plantain is quite often administered in dyspepsia in this part of the country. This has led to the belief that ripe and unripe banana may also be a bland fruit. Hence this present study was undertaken to assess the Ameliorating Effects of Ethanoic Extract of Ripe and unripe Banana fruits in salt loaded, Alcoholic and indomethacin induced Ulcerative Rats. Eighty male wistar rats (weighing between 120-140g were grouped into 16 standard study groups of 5 animals each. Group A: Control group this group received food and water only. Group Bi: Ulcer induced by indometacine (NSAID) without treatment Group Bii: Ulcer (Alcohol) without treatment Group C: Received Sodium chloride orally for 2 weeks without treatment, Group Di: Received Sodium chloride orally all through the study (NaCl)+ Ulcer (NSAID) without treatment Group Dii: Received Sodium chloride orally all through the study (NaCl)+ Ulcer (Alcohol ) without treatment, each of the group were treated with unripe banana extract and ripe banana extract, all animals were sacrificed after exposure to chloroform. Data obtained were analyzed as mean ± standard deviation using one way analysis of variance (ANOVA. Level of significance between groups was taken as p<0.05. There was significant decrease in the Ulcer Index of all the experiment groups when compared to Ulcer without treatment group. This is an indication that both ripe and unripe banana has protective effect on both ulcer induced by NSAID and Alcohol. It is worth concluding that excessive Nacl intake could increase susceptibility to ulcer.