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Specific Parameters of Methemoglobinemia are Hereditary that is Enzyme Deficiency as well as Acquired Methemoglobinemia, Diagnosis and Differential Diagnosis

Srinivas G., Ramanjaneyulu D.V., Muralinath E., Guruprasad M., Sravani Pragna K., Manjari P., Sony Sharlet E., T. Nikhil, V. Yaswanth Sai, D. Kusuma Latha, R. Faith Rani, P. Megha Varna

Abstract


An uncommon condition known as methemoglobinemia is caused by the oxidation of divalent ferro-iron of hemoglobin (Hb) to ferri-iron of methemoglobin (MetHb). Methemoglobinemia may result in acquired or inherited mechanisms. The most prevalent types are acquired, primarily as a result of exposure to chemicals that directly or indirectly oxidize yellow blood cells. Inherited forms, known as HbM sickness, are caused by autosomal dominant mutations in the globin genes or autosomal recessive variants in the CYB5R3 gene. Our recommendations are dependent upon a systematic literature search. A series of questions regarding the key signs and symptoms, the methods for diagnosis, were formulated and the relative recommendations were produced. An agreement was obtained using a Delphi-like approach.


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