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An Essential Parameters of Clostridium Perfringens Infection Include Objectives, Etiology, Epidemiology, Pathophysiology, Histopathophysiology, Diagnosis, Differential Diagnosis, Treatment and Prognosis
Abstract
The anaerobic Gram-positive spore-forming bacillus Clostridium perfringens is linked to acute gastrointestinal infections in people that range in severity from diarrhea to necrotizing enterocolitis and myonecrosis. This pathogen can produce spores that are resistant to environmental stress and has an arsenal of poisons necessary for disease development. Spores of C. perfringens may withstand typical cooking temperatures. Therefore, it can expand in foods that are improperly stored. Outbreaks are most commonly related to improperly heated or reheated gravy, poultry, or meats. The epidemiology, pathophysiology, and other important aspects relevant to the interprofessional team's treatment of patients with Clostridium perfringens infections will be explained in this activity.
References
Lucey, B. P., & Hutchins, G. M. (2004). William H. Welch, MD, and the discovery of Bacillus welchii. Archives of Pathology & Laboratory Medicine, 128(10), 1193–1195. https://doi.org/10.5858/2004-128-1193-WHWMDA
Navarro, M. A., McClane, B. A., & Uzal, F. A. (2018). Mechanisms of action and cell death associated with Clostridium perfringens toxins. Toxins, 10(5), 212. https://doi.org/10.3390/toxins10050212
Grass, J. E., Gould, L. H., & Mahon, B. E. (2013). Epidemiology of foodborne disease outbreaks caused by Clostridium perfringens, United States, 1998–2010. Foodborne Pathogens and Disease, 10(2), 131–136. https://doi.org/10.1089/fpd.2012.1316
Dewey-Mattia, D., Manikonda, K., Hall, A. J., Wise, M. E., & Crowe, S. J. (2018). Surveillance for foodborne disease outbreaks—United States, 2009–2015. MMWR Surveillance Summaries, 67(10), 1–11. https://doi.org/10.15585/mmwr.ss6710a1
Scallan, E., Hoekstra, R. M., Angulo, F. J., Tauxe, R. V., Widdowson, M. A., Roy, S. L., Jones, J. L., & Griffin, P. M. (2011). Foodborne illness acquired in the United States—Major pathogens. Emerging Infectious Diseases, 17(1), 7–15. https://doi.org/10.3201/eid1701.P11101
Ma, M., Li, J., & McClane, B. A. (2012). Genotypic and phenotypic characterization of Clostridium perfringens isolates from Darmbrand cases in post-World War II Germany. Infection and Immunity, 80(12), 4354–4363. https://doi.org/10.1128/IAI.00818-12
Poka, H., & Duke, T. (2003). In search of pigbel: Gone or just forgotten in the highlands of Papua New Guinea? Papua New Guinea Medical Journal, 46(3–4), 135–142.
Duke, T., Poka, H., Myers, S., Radcliffe, J., & Pavlin, B. I. (2013). Pigbel in the 21st century: Still here, and still in need of an effective surveillance system. Papua New Guinea Medical Journal, 56(3–4), 136–140.
Chi, C. H., Chen, K. W., Huang, J. J., Chuang, Y. C., & Wu, M. H. (1995). Gas composition in Clostridium septicum gas gangrene. Journal of the Formosan Medical Association, 94(12), 757–759.
Titball, R. W., Naylor, C. E., & Basak, A. K. (1999). The Clostridium perfringens alpha-toxin. Anaerobe, 5(2), 51–64. https://doi.org/10.1006/anae.1999.0192
Takehara, M., Takagishi, T., Seike, S., Ohtani, K., Kobayashi, K., Miyamoto, K., Shimizu, T., & Nagahama, M. (2016). Clostridium perfringens α-toxin impairs innate immunity via inhibition of neutrophil differentiation. Scientific Reports, 6, 28192. https://doi.org/10.1038/srep28192
Nagahama, M., Ochi, S., Oda, M., Miyamoto, K., Takehara, M., & Kobayashi, K. (2015). Recent insights into Clostridium perfringens beta-toxin. Toxins, 7(2), 396–406. https://doi.org/10.3390/toxins7020396
Popoff, M. R. (2011). Epsilon toxin: A fascinating pore-forming toxin. FEBS Journal, 278(23), 4602–4615. https://doi.org/10.1111/j.1742-4658.2011.08145.x
Takehara, M., Takagishi, T., Seike, S., Oda, M., Sakaguchi, Y., Hisatsune, J., Ochi, S., Kobayashi, K., & Nagahama, M. (2017). Cellular entry of Clostridium perfringens iota-toxin and Clostridium botulinum C2 toxin. Toxins, 9(8), 247. https://doi.org/10.3390/toxins9080247
Keyburn, A. L., Boyce, J. D., Vaz, P., Bannam, T. L., Ford, M. E., Parker, D., Di Rubbo, A., Rood, J. I., & Moore, R. J. (2008). NetB, a new toxin that is associated with avian necrotic enteritis caused by Clostridium perfringens. PLoS Pathogens, 4(2), e26. https://doi.org/10.1371/journal.ppat.0040026
Awad, M. M., Ellemor, D. M., Boyd, R. L., Emmins, J. J., & Rood, J. I. (2001). Synergistic effects of alpha-toxin and perfringolysin O in Clostridium perfringens-mediated gas gangrene. Infection and Immunity, 69(12), 7904–7910. https://doi.org/10.1128/IAI.69.12.7904-7910.2001
Kiu, R., & Hall, L. J. (2018). An update on the human and animal enteric pathogen Clostridium perfringens. Emerging Microbes & Infections, 7(1), 141. https://doi.org/10.1038/s41426-018-0144-8
Buboltz, J. B., & Murphy-Lavoie, H. M. (2023). Gas gangrene. In StatPearls. StatPearls Publishing. https://www.ncbi.nlm.nih.gov/books/NBK537030/
Basta, M., & Annamaraju, P. (2023). Bacterial spores. In StatPearls. StatPearls Publishing. https://www.ncbi.nlm.nih.gov/books/NBK537030/
Bätge, B., Filejski, W., Kurowski, V., Klüter, H., & Djonlagic, H. (1992). Clostridial sepsis with massive intravascular hemolysis: Rapid diagnosis and successful treatment. Intensive Care Medicine, 18(8), 488–490. https://doi.org/10.1007/BF01694349
van Bunderen, C. C., Bomers, M. K., Wesdorp, E., Peerbooms, P., & Veenstra, J. (2010). Clostridium perfringens septicaemia with massive intravascular haemolysis: A case report and review of the literature. Netherlands Journal of Medicine, 68(9), 343–346.
Matsuda, T., Okada, Y., Inagi, E., Tanabe, Y., Shimizu, Y., Nagashima, K., Sakurai, J., Nagahama, M., & Tanaka, S. (2007). Enteritis necroticans ("pigbel") in a Japanese diabetic adult. Pathology International, 57(9), 622–626. https://doi.org/10.1111/j.1440-1827.2007.02149.x
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