Open Access Open Access  Restricted Access Subscription Access

An Important Parameters of Hematopoietic Stem Cell Include Anatomy as Well as Physiology, Indications, Treatment, Complications and Clinical Significance

Srinivas G., Ramanjaneyulu D.V., Muralinath E., Guruprasad M., Sravani Pragna K., Manjari P., Sony Sharlet E., T. Nikhil, V. Yaswanth Sai, D. Kusuma Latha, Ch. Ramya Sudha, Sridevi. K., D. Gokul Shiva Balaji

Abstract


Since the Sickle Cell Anemia Act, there has been a steady improvement in sickle cell disease screening and treatment. Although new medical treatments have been developed, sickle cell disease is still incurable for the majority of those affected, and the only cure for those who have sickle cell disease is hematopoietic stem cell transplantation. Autologous hematopoietic stem cell transplantation involves genetically modifying the patient's stem cells to correct the genetic mutation that causes sickle cell disease. Allogeneic hematopoietic stem cell transplantation replaces the damaged stem cells with healthy stem cells from a suitable donor. The majority of patients respond well to HSCT, although there are serious toxicities and sometimes fatal side effects associated with the surgery. Patients must be carefully chosen for HSCT. In addition to highlighting the importance of the interprofessional team in the care of patients undergoing the procedure, this exercise discusses the therapeutic significance of HSCT in sickle cell disease.


Full Text:

PDF

References


Pontikoglou, C., Deschaseaux, F., Sensebé, L., & Papadaki, H. A. (2011). Bone marrow mesenchymal stem cells: Biological properties and their role in hematopoiesis and hematopoietic stem cell transplantation. Stem Cell Reviews and Reports, 7(3), 569–589. https://doi.org/10.1007/s12015-011-9226-5

Barriga, F., Ramírez, P., Wietstruck, A., & Rojas, N. (2012). Hematopoietic stem cell transplantation: Clinical use and perspectives. Biological Research, 45(3), 307–316. https://doi.org/10.4067/S0716-97602012000300005

Lee, J. Y., & Hong, S. H. (2020). Hematopoietic stem cells and their roles in tissue regeneration. International Journal of Stem Cells, 13(1), 1–12. https://doi.org/10.15283/ijsc19147

Fliedner, T. M. (1998). The role of blood stem cells in hematopoietic cell renewal. Stem Cells, 16(6), 361–374. https://doi.org/10.1002/stem.160361

Mousaei Ghasroldasht, M., Seok, J., Park, H. S., Liakath Ali, F. B., & Al-Hendy, A. (2022). Stem cell therapy: From idea to clinical practice. International Journal of Molecular Sciences, 23(5), 2850. https://doi.org/10.3390/ijms23052850

Riezzo, I., Pascale, N., La Russa, R., Liso, A., Salerno, M., & Turillazzi, E. (2017). Donor selection for allogenic hemopoietic stem cell transplantation: Clinical and ethical considerations. Stem Cells International, 2017, 5250790. https://doi.org/10.1155/2017/5250790

Aggarwal, R., Lu, J., Pompili, V. J., & Das, H. (2012). Hematopoietic stem cells: Transcriptional regulation, ex vivo expansion and clinical application. Current Molecular Medicine, 12(1), 34–49. https://doi.org/10.2174/156652412798376101

Hoffbrand, A. V. (2024). Hoffbrand’s essential haematology (8th ed.). John Wiley & Sons.

Watt, F. M., & Driskell, R. R. (2010). The therapeutic potential of stem cells. Philosophical Transactions of the Royal Society B: Biological Sciences, 365(1537), 155–163. https://doi.org/10.1098/rstb.2009.0149

Mittermayr, R., Antonic, V., Hartinger, J., Kaufmann, H., Redl, H., Téot, L., ... & Schaden, W. (2012). Extracorporeal shock wave therapy (ESWT) for wound healing: Technology, mechanisms, and clinical efficacy. Wound Repair and Regeneration, 20(4), 456–465. https://doi.org/10.1111/j.1524-475X.2012.00796.x

Ji, H., Hu, C., Yang, X., Liu, Y., Ji, G., Ge, S., ... & Wang, M. (2023). Lymph node metastasis in cancer progression: Molecular mechanisms, clinical significance and therapeutic interventions. Signal Transduction and Targeted Therapy, 8(1), 367. https://doi.org/10.1038/s41392-023-01478-1

Makris, E. A., Hadidi, P., & Athanasiou, K. A. (2011). The knee meniscus: Structure–function, pathophysiology, current repair techniques, and prospects for regeneration. Biomaterials, 32(30), 7411–7431. https://doi.org/10.1016/j.biomaterials.2011.06.037

Borena, B. M., Martens, A., Broeckx, S. Y., Meyer, E., Chiers, K., Duchateau, L., & Spaas, J. H. (2015). Regenerative skin wound healing in mammals: State-of-the-art on growth factor and stem cell based treatments. Cellular Physiology and Biochemistry, 36(1), 1–23. https://doi.org/10.1159/000376454

Krishnasamy, S., & Abell, T. L. (2018). Diabetic gastroparesis: Principles and current trends in management. Diabetes Therapy, 9, 1–42. https://doi.org/10.1007/s13300-017-0334-9

Bharuka, T., Reche, A., & Bharuka, T. Jr. (2024). Advancements in periodontal regeneration: A comprehensive review of stem cell therapy. Cureus, 16(2). https://doi.org/10.7759/cureus.44022

Robijns, J., Nair, R. G., Lodewijckx, J., Arany, P., Barasch, A., Bjordal, J. M., ... & WALT Working Group. (2022). Photobiomodulation therapy in management of cancer therapy-induced side effects: WALT position paper 2022. Frontiers in Oncology, 12, 927685. https://doi.org/10.3389/fonc.2022.927685

Holland, E. J. (2015). Management of limbal stem cell deficiency: A historical perspective, past, present, and future. Cornea, 34(Suppl. 10), S9–S15. https://doi.org/10.1097/ICO.0000000000000605

Mazini, L., Ezzoubi, M., & Malka, G. (2021). Overview of current adipose-derived stem cell (ADSCs) processing involved in therapeutic advancements: Flow chart and regulation updates before and after COVID-19. Stem Cell Research & Therapy, 12(1), 1. https://doi.org/10.1186/s13287-021-02150-9

Lanza, R., Langer, R., Vacanti, J. P., & Atala, A. (Eds.). (2020). Principles of tissue engineering (5th ed.). Academic Press.

Gu, X., Yu, X., Zhao, C., Duan, P., Zhao, T., Liu, Y., ... & Wang, Y. (2018). Efficacy and safety of autologous bone marrow mesenchymal stem cell transplantation in patients with diabetic retinopathy. Cellular Physiology and Biochemistry, 49(1), 40–52. https://doi.org/10.1159/000492070

Kumar, P., Kandoi, S., Misra, R., Vijayalakshmi, S., Rajagopal, K., & Verma, R. S. (2019). The mesenchymal stem cell secretome: A new paradigm towards cell-free therapeutic mode in regenerative medicine. Cytokine & Growth Factor Reviews, 46, 1–9. https://doi.org/10.1016/j.cytogfr.2019.01.002

Openshaw, H., Nash, R. A., & McSweeney, P. A. (2002). High-dose immunosuppression and hematopoietic stem cell transplantation in autoimmune disease: Clinical review. Biology of Blood and Marrow Transplantation, 8(5), 233–248. https://doi.org/10.1053/bbmt.2002.v8.pm12064361

Pittenger, M. F., Discher, D. E., Péault, B. M., Phinney, D. G., Hare, J. M., & Caplan, A. I. (2019). Mesenchymal stem cell perspective: Cell biology to clinical progress. NPJ Regenerative Medicine, 4(1), 22. https://doi.org/10.1038/s41536-019-0083-6

Niscola, P., Romani, C., Cupelli, L., Scaramucci, L., Tendas, A., Dentamaro, T., ... & de Fabritiis, P. (2007). Mucositis in patients with hematologic malignancies: An overview. Haematologica, 92(2), 222–231. https://doi.org/10.3324/haematol.11306

Fadini, G. P., & Avogaro, A. (2010). Potential manipulation of endothelial progenitor cells in diabetes and its complications. Diabetes, Obesity and Metabolism, 12(7), 570–583. https://doi.org/10.1111/j.1463-1326.2010.01195.x


Refbacks

  • There are currently no refbacks.