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Evaluating the Prevailing Determinants of Female Infertility in Relation To Blood Group, Genotype, Rhesus Factor and Hormonal Profile in Some Selected Hospitals in Abia State, Nigeria
Abstract
Female infertility is well-known health problem globally in obstetrics and gynaecology. This work is aim at evaluating the prevailing determinants of female infertility in some selected hospitals in Umuahia, Abia State; The aim of this study is to evaluate the relationship between blood group, genotypes, rhesus factor; and reproductive hormones; age and hormonal imbalance at basal level. Structured self-administered questionnaires were distributed to 190 infertile women from the two fertility clinics in Umuahia to obtain their physiological parameters. (10ml) was collected from each of the participant, 5ml each was placed in plain and heparinized bottles respectively, whole blood was used to determine the heamatological parameters such as blood group, Rhesus factor and genotype while samples in heparinised bottles were centrifuged at 2000rpm for 15 minutes and used for hormonal assay. The results obtained were statistically computed using GRAPHPAD PRISM 6.0. All data were presented as mean ± standard error of mean (SEM) and were analysed using the Analysis of variance (ANOVA). Multiple comparisons were done using Turkey method. Differences were declared statistically significant at p < 0.05. Participants which blood group A. Showed higher level of prolactin (PRL) compared to other blood groups whereas the levels of follicle stimulating hormone, luteinising hormone were higher in blood group O compared to other group. Participants of the oldest age group (51-55year) had elevated levels of reproductive hormones compared to other age groups. Participants with heterozygous genotype AS had higher basal level of prolactin (PRL) and luteinising hormone (LH) while participants with homozygous genotype AA showed a high basal level ofFSH. Therefore, this study established relationship between age and female infertility while suggesting that age affect fertility via imbalance in basal level of reproduction hormones. It also showed no association between blood group, genotype, rhesus factor to female infertility.
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