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Exploring Drugs Targeting Neuroglial Disorders: A Comprehensive Overview

Muralinath E., Pooja Devi, Prasanta Chbukdhara, Sanjib Borah, Kalyan C., Archana Jain, Guruprasad M.

Abstract


Neurological  disorders affect the intricate network of cells in the central nervous  system (CNS) , along with  neurons and glial cereals.  Glial cells namely  atrocities, oligodendro cytes and microbial play an important violence in controlling  neural function, synaptic plasticity and overall CNS  homeostasis. Anti_ inflammatory  agents, namely NSAID and corticosteroids, have been explored for their potentiality in mitigating astrocyre _ mediated inflammation. Disease  modifying drugs  Including interferon and mono clonal antibodies, aim  to modulate  the immune  response  and decrease demyelination specifically  in multiple sclerosis patients.  Minocycline, an  antibiotic with anti_ inflammatory properties, has proved  beneficial effect in attenuating microbial activation  and decreases neuro inflammation in many  experimental models.  Targeting  glial fibrillary acidic protein ( GFAD ) , a marker for reactive atrocities has gained popularity.  Small molecules  and gene therapies aimed at modulating GFAP expression  exhibit promise in regulating  astrocyte reactivity  and potentially  decreasing the progression  of  neurological  disorders. Finally  it is concluded  that the exploration  of rugs  targeting neurological disorders represents a promising avenue particularly  in neuro science  research.


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References


Radiopedia Glial cells Available from: https://radiopaedia.org/articles/glial-cells(last accessed 18.12.2020)

• Yuhas D, Jabr F. Know Your Neurons: What Is the Ratio of Glia to Neurons in the Brain?.Available from; https://blogs.scientificamerican.com/brainwaves/know-your-neurons-what-is-the-ratio-of-glia-to-neurons-in-the-brain/(last accessed 18.12.2020)

• • Queensland Brain Institute Types of Glia Available:https://qbi.uq.edu.au/brain-basics/brain/brain-physiology/types-glia (accessed 21.1.2023)

• • Ludwig PE, Das JM. Histology, glial cells. InStatPearls [Internet] 2021 May 10. StatPearls Publishing.Available:https://www.ncbi.nlm.nih.gov/books/NBK441945/ (accessed 21.1.2023)

• • Biology Dic Glial cells Available:https://biologydictionary.net/glial-cells/ (accessed 10.5.2022)

• • Washington Faculty neuroscience for kids Available from:https://faculty.washington.edu/chudler/glia.html (accessed 18.12.2020)

• • radiopedia glymphatic pathway Available from:https://radiopaedia.org/articles/glymphatic-pathway?lang=gb (accessed 18.12.2020)

• • Ludwig PE, Das JM. Histology, Glial Cells. StatPearls [Internet]. 2020 Jun 19.Available from:https://www.ncbi.nlm.nih.gov/books/NBK441945/ (accessed 18.12.2020)

• • Arellano JI, Morozov YM, Micali N, Rakic P. Radial glial cells: new views on old questions. Neurochemical research. 2021 Oct;46(10):2512-24. Available:https://pubmed.ncbi.nlm.nih.gov/33725233/ (accessed 25.1.2023)

• • Psychology Wiki. Radial Glia Available from: https://psychology.wikia.org/wiki/Radial_glial_cells (accessed 19.12.20200

• • Scanlon ST. Depressing effects of microglia. Science. 2020 Apr 17;368(6488):279-80.Available from;https://science.sciencemag.org/content/368/6488/279.2.full (last accessed 18.12.2020)

• • Wake H, Moorhouse AJ, Nabekura J. Functions of microglia in the central nervous system-beyond the immune response. Neuron glia biology. 2011 Feb 1;7(1):47.Available from:https://www.cambridge.org/core/journals/neuron-glia-biology/article/abs/functions-of-microglia-in-the-central-nervous-system-beyond-the-immune-response/B262044DDADE74974C8A268DD258B29A (accessed 18.12.2020)


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