Open Access Open Access  Restricted Access Subscription Access

Understanding the Impact of Drugs on Muscle Spindle Disorders in Humans

Gnana Lahari R, Muralinath E., Pooja Devi, Prasanta Chbukdhara, Sanjib Borah, Kalyan C., Archana Jain, Guruprasad M., Sai Kumar M, Poojitha P, Bharat M

Abstract


        Dysfunction  of muscle spindles can result in various disorders, impacting motor control as well as coordination. Drugs classified as muscle relaxants such as benzodiazepines and baclofen, directly  target the central nervous system to decrease muscle tone. Opioid can interfere with the processing of sensory information, including signals from muscle spindles. Neuro muscular blocking drugs are used during surgical procedures to induce muscle relaxation. Strategies to mitigate drug_ induced  muscle spindles dysfunction  may include dose optimization, combination therapies and alternative pharmacological approaches. Finally it is concluded  that the impact of drugs on muscle spindle disorders represents a complex  interplay between pharmacology, neuro physiology and clinical medicine.


Full Text:

PDF

References


Kröger S, Watkins B. Muscle spindle function in healthy and diseased muscle. Skeletal muscle. 2021 Dec;11(1):1-3. [1]

Proske U, Gandevia SC. The kinaesthetic senses. The Journal of physiology. 2009 Sep 1;587(17):4139-46.

Kröger S, Watkins B. Muscle spindle function in healthy and diseased muscle. Skeletal Muscle. 2021 Dec;11(1):1-3.

Golgi Tendon Organs and Muscle Spindles Explained. Available from:https://www.acefitness.org/fitness-certifications/ace-answers/exam-preparation-blog/5336/golgi-tendon-organs-and-muscle-spindles-explained/ (Accessed, 17.5.2021).

Brukner P. Brukner & Khan's clinical sports medicine. North Ryde: McGraw-Hill; 2012.

Animated Anatomy. Muscle Spindle - Muscle Stretch Reflex. Available from: https://www.youtube.com/watch?v=442UbX9qeLk [Accessed, 08/10/2021]

https://kin450-neurophysiology.wikispaces.com/Muscle+Spindle

Young RR. Spasticity: a review. Neurology. 1994 Nov;44(11 Suppl 9):S12-20.

Thomas RC, Wilson VJ. Precise localization of Renshaw cells with a new marking technique. Nature. 1965 Apr 10;206(4980):211-3.

Mukherjee A, Chakravarty A. Spasticity mechanisms–for the clinician. Frontiers in neurology. 2010;1.

Wilson LR, Gandevia SC, Inglis JT, Gracies JM, Burke D. Muscle spindle activity in the affected upper limb after a unilateral stroke. Brain. 1999 Nov 1;122(11):2079-88.

Ribot‐Ciscar E, Tréfouret S, Aimonetti JM, Attarian S, Pouget J, Roll JP. Is muscle spindle proprioceptive function spared in muscular dystrophies? A muscle tendon vibration study. Muscle & Nerve: Official Journal of the American Association of Electrodiagnostic Medicine. 2004 Jun;29(6):861-6.

. Muller KA, Ryals JM, Feldman EL, Wright DE. Abnormal muscle spindle innervation and large-fiber neuropathy in diabetic mice. Diabetes. 2008;57(6):1693–1701. doi: 10.2337/db08-0022. [PubMed] [CrossRef] [Google Scholar]

. Swash M, Fox KP. The pathology of the muscle spindle in myasthenia gravis. J Neurol Sci. 1975;26(1):39–47. doi: 10.1016/0022-510X(75)90112-4. [PubMed] [CrossRef] [Google Scholar]

Cazzato G, Walton JN. The pathology of the muscle spindle. A study of biopsy material in various muscular and neuromuscular diseases. J Neurol Sci. 1968;7(1):15–70. doi: 10.1016/0022-510X(68)90003-8. [PubMed] [CrossRef] [Google Scholar]

Vaughan SK, Kemp Z, Hatzipetros T, Vieira F, Valdez G. Degeneration of proprioceptive sensory nerve endings in mice harboring amyotrophic lateral sclerosis-causing mutations. J Comp Neurol. 2015;523(17):2477–2494. doi: 10.1002/cne.23848. [PMC free article] [PubMed] [CrossRef] [Google Scholar]

Sangari S, Iglesias C, El Mendili MM, Benali H, Pradat PF, Marchand-Pauvert V. Impairment of sensory-motor integration at spinal level in amyotrophic lateral sclerosis. Clin Neurophysiol. 2016;127(4):1968–1977. doi: 10.1016/j.clinph.2016.01.014. [PubMed] [CrossRef] [Google Scholar]

Sabado J, Casanovas A, Tarabal O, Hereu M, Piedrafita L, Caldero J, et al. Accumulation of misfolded SOD1 in dorsal root ganglion degenerating proprioceptive sensory neurons of transgenic mice with amyotrophic lateral sclerosis. Biomed Res Int. 2014;2014:852163. doi: 10.1155/2014/852163. [PMC free article] [PubMed] [CrossRef] [Google Scholar]

Seki S, Yamamoto T, Quinn K, Spigelman I, Pantazis A, Olcese R, et al. Circuit-specific early impairment of proprioceptive sensory neurons in the SOD1(G93A) Mouse Model for ALS. J Neurosci. 2019;39(44):8798–8815. doi: 10.1523/JNEUROSCI.1214-19.2019. [PMC free article] [PubMed] [CrossRef] [Google Scholar]

Powis RA, Gillingwater TH. Selective loss of alpha motor neurons with sparing of gamma motor neurons and spinal cord cholinergic neurons in a mouse model of spinal muscular atrophy. J Anat. 2016;228(3):443–451. doi: 10.1111/joa.12419. [PMC free article] [PubMed] [CrossRef] [Google Scholar]

Lalancette- Hebert M, Sharma A, Lyashchenko AK, Shneider NA. Gamma motor neurons survive and exacerbate alpha motor neuron degeneration in ALS. Proc Natl Acad Sci U S A. 2016;113(51):E8316–E8E25. doi: 10.1073/pnas.1605210113. [PMC free article] [PubMed] [CrossRef] [Google Scholar]


Refbacks

  • There are currently no refbacks.