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Comparative Study of Lipid Profile in Menopausal and Non-Menopausal Adult Female (Ldl, Hdl, Total Cholesterol, Tryglycyride)

Edebiri O. E., Akpe P. E., Akpotaire P. A., Ugar E. B, Aichienede I. J., Olurinola E. F., Asekhamen E. H.

Abstract


The alterations in lipid metabolism during menopause have significant implications for cardiovascular health. This study was aimed at evaluating the lipid profile in menopausal and non-menopausal adults’ females. Consenting participants had their venous blood drawn in five milliliters (5 ml) and put into a sample bottle with lithium heparin. Following ten minutes of spinning blood samples in a bucket centrifuge at 2500 RPM (rounds per minute), plasma was collected, frozen in plain sample bottles, and examined for the concentrations of oxidative biomarkers and lipid profiles. Data was analyzed using descriptive statistics to determine the mean, standard deviation, and range of lipid profile in premenopausal and postmenopausal women. Independent sample t-tests will be used to compare lipid profile between premenopausal and postmenopausal women, Data analysis was done with Graph Pad prism version 8.0.1 (244). The results were expressed as means ± SEM. The results obtained from the current study shows that the mean values of Low-density lipoprotein-cholesterol level in the non-menopausal and menopausal adult female groups were 86.40±11.06 and 127.4±11.06 respectively.  Besides low-density lipoprotein cholesterol (LDL-c), High density lipoprotein cholesterol (HDL-C) has also been reported to altered by hormonal imbalances in menopausal transition. The results obtained from the current study shows that the mean values of high-density lipoprotein cholesterol (HDL-c) in the non-menopausal and menopausal adult female groups were 52.90±8.474 and 71.20±8.474 respectively. The results obtained from the current study shows that the mean values of Total Cholesterol level in the non-menopausal and menopausal adult female groups were 161.4±10.39 and 182.9±10.39 respectively. At the end of this experimental study, the following were inferred; that the Lipid profile namely Low-density lipoprotein cholesterol and high-density lipoprotein level in menopausal and non-menopausal adult female were investigated. That comparatively, there was a statistically significant difference both of Low-density lipoprotein cholesterol and high-density lipoprotein level between the menopausal and non-menopausal adult female. This were characterized by raised LDL-C & HDL-C values in menopausal than the non-menopausal adult female group. However, while the findings regard LDL-C suggest an increased cardiovascular risk associated with menopause-related lipid changes. The significance of that of HDL-C suggest otherwise.


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